Date published: 2026-4-1

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Docosahexaenoic Acid ethyl ester (CAS 81926-94-5)

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Alternate Names:
Cervonic Acid ethyl ester; DHA ethyl ester
Application:
Docosahexaenoic Acid ethyl ester is an alternate form of Docosahexaenoic acid (DHA) and a ethyl ester derivative
CAS Number:
81926-94-5
Molecular Weight:
356.55
Molecular Formula:
C24H36O2
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Docosahexaenoic Acid Ethyl Ester, identified by CAS number 1020718-25-5, is an ethyl ester derivative of Docosahexaenoic Acid (DHA), an omega-3 fatty acid that is vital for maintaining the structural integrity of cell membranes, particularly in the brain and retina. The modification of DHA to its ethyl ester form enhances its stability and solubility, making it more suitable for use in various research settings. In biochemical studies, this compound is used to explore the mechanisms through which omega-3 fatty acids influence cellular functions. Docosahexaenoic Acid Ethyl Ester is particularly valuable in investigations focusing on the modulation of lipid rafts within cellular membranes. These rafts are rich in cholesterol and sphingolipids, and they play critical roles in cell signaling and the organization of membrane proteins. By integrating into these structures, DHA ethyl ester can affect raft fluidity and, consequently, the signaling pathways that depend on these membrane domains. Additionally, research utilizes this compound to study its impact on the expression and activity of enzymes involved in lipid metabolism, such as those in the pathways of inflammation and antioxidant defense. These studies help explain how alterations in lipid composition can affect cellular processes and membrane dynamics, without the direct implications of clinical or therapeutic contexts.


Docosahexaenoic Acid ethyl ester (CAS 81926-94-5) References

  1. Intakes of dietary docosahexaenoic acid ethyl ester and egg phosphatidylcholine improve maze-learning ability in young and old mice.  |  Lim, SY. and Suzuki, H. 2000. J Nutr. 130: 1629-32. PMID: 10827221
  2. Autoxidation kinetic analysis of docosahexaenoic acid ethyl ester and docosahexaenoic triglyceride with oxygen sensor.  |  Yoshii, H., et al. 2002. Biosci Biotechnol Biochem. 66: 749-53. PMID: 12036046
  3. Divergent effects of eicosapentaenoic and docosahexaenoic acid ethyl esters, and fish oil on hepatic fatty acid oxidation in the rat.  |  Hong, DD., et al. 2003. Biochim Biophys Acta. 1635: 29-36. PMID: 14642774
  4. Effect of supplementation with docosahexaenoic acid ethyl ester and sn-2 docosahexaenyl monoacylglyceride on plasma and erythrocyte fatty acids in rats.  |  Valenzuela, A., et al. 2005. Ann Nutr Metab. 49: 49-53. PMID: 15735367
  5. Enzymes and receptors of prostaglandin pathways with arachidonic acid-derived versus eicosapentaenoic acid-derived substrates and products.  |  Wada, M., et al. 2007. J Biol Chem. 282: 22254-66. PMID: 17519235
  6. Ethyl docosahexaenoate decreased Neoral absorption due to particle size enlargement.  |  Hirunpanich, V., et al. 2008. Int J Pharm. 361: 251-2. PMID: 18577438
  7. Docosahexaenoic acid ethyl ester enhances 6-hydroxydopamine-induced neuronal damage by induction of lipid peroxidation in mouse striatum.  |  Kabuto, H., et al. 2009. Neurochem Res. 34: 1299-303. PMID: 19219632
  8. Kinetics of docosahexaenoic acid ethyl ester accumulation in dog plasma and brain.  |  Dahms, I., et al. 2016. Prostaglandins Leukot Essent Fatty Acids. 113: 1-8. PMID: 27720035
  9. [Separation of eicosapentaenoic acid ethyl ester and docosahexaenoic acid ethyl ester by simulated moving bed chromatography].  |  Dong, Q., et al. 2018. Se Pu. 36: 858-865. PMID: 30251513
  10. A biphasic system based on guanidinium ionic liquid: Preparative separation of eicosapentaenoic acid ethyl ester and docosahexaenoic acid ethyl ester by countercurrent chromatography.  |  Fan, C., et al. 2020. J Chromatogr A. 1618: 460872. PMID: 31959458

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Docosahexaenoic Acid ethyl ester, 50 mg

sc-205296
50 mg
$40.00

Docosahexaenoic Acid ethyl ester, 100 mg

sc-205296A
100 mg
$71.00