DNER Antibody (YY-7): sc-100305

DNER Antibody (YY-7) is a mouse monoclonal IgG3 kappa light chain antibody that detects DNER protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). anti-DNER antibody (YY-7) is available as a non-conjugated format. DNER protein, or Delta-notch-like EGF-related receptor, plays a critical role in the central nervous system as a neuron-specific, atypical Notch ligand, primarily expressed in dendrites and cell bodies of neurons. Notably, DNER contains ten extracellular EGF-like domains that share significant homology with Notch ligand, Delta, which is essential for mediating neuron-glia interactions during astrocytogenesis. This interaction occurs at contacts between Purkinje cells and Bergmann glia, where DNER directly engages with Notch 1, activating a Deltex-dependent Notch signaling pathway vital for morphogenesis of Bergmann glia. Proper functioning of DNER is crucial for maturation of glial cells, and studies have shown that DNER-knockout mice exhibit severe motor discoordination and impaired cerebellar morphogenesis, underscoring DNER′s importance in neural development and function.

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DNER Antibody (YY-7) References:

1. Delta/notch-like epidermal growth factor (EGF)-related receptor, a novel EGF-like repeat-containing protein targeted to dendrites of developing and adult central nervous system neurons.  |  Eiraku, M., et al. 2002. J Biol Chem. 277: 25400-7. PMID: 11950833
2. The gene expression profile of extraskeletal myxoid chondrosarcoma.  |  Subramanian, S., et al. 2005. J Pathol. 206: 433-44. PMID: 15920699
3. DNER acts as a neuron-specific Notch ligand during Bergmann glial development.  |  Eiraku, M., et al. 2005. Nat Neurosci. 8: 873-80. PMID: 15965470
4. Impaired cerebellar functions in mutant mice lacking DNER.  |  Tohgo, A., et al. 2006. Mol Cell Neurosci. 31: 326-33. PMID: 16298139
5. Notch1 signaling regulates radial glia differentiation through multiple transcriptional mechanisms.  |  Patten, BA., et al. 2006. J Neurosci. 26: 3102-8. PMID: 16554461
6. Nas transgenic mouse line allows visualization of Notch pathway activity in vivo.  |  Souilhol, C., et al. 2006. Genesis. 44: 277-86. PMID: 16708386
7. DNER as key molecule for cerebellar maturation.  |  Saito, SY. and Takeshima, H. 2006. Cerebellum. 5: 227-31. PMID: 16997755
8. Notch signaling in gastrointestinal tract (review).  |  Katoh, M. and Katoh, M. 2007. Int J Oncol. 30: 247-51. PMID: 17143535
9. Proteomic analysis of cathepsin B- and L-deficient mouse brain lysosomes.  |  Stahl, S., et al. 2007. Biochim Biophys Acta. 1774: 1237-46. PMID: 17765022

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-DNER Antibody (YY-7) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-DNER Antibody (YY-7) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

DNER Antibody (YY-7) Specifications

Alternate Product Name: DNER

Product Clone Name: YY-7

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₃ kappa light chain

Amino Acids: 368-477

Epitope Target: DNER

Epitope Species: human

Product Reactivity/Detection: DNER

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, ELISA

Vialing Information: Each vial contains 100 µg IgG₃ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for DNER Antibody (YY-7): N/A