DND1 Antibody (X22): sc-130493

DND1 Antibody (X22) is a mouse monoclonal IgG2a kappa light chain antibody that detects DND1 protein of mouse, rat, and human origin by western blotting (WB) and immunoprecipitation (IP). DND1 (X22) antibody is available as the non-conjugated anti-DND1 antibody. DND1 protein, also known as dead end protein homolog 1 or RBMS4 (RNA-binding motif, single-stranded-interacting protein 4), is a crucial 353 amino acid protein characterized by the presence of two RNA recognition motif (RRM) domains. DND1 is specifically expressed in primordial germ cells (PGCs) during embryogenesis, where DND1 localizes to perinuclear germ granules. This localization suggests a role in regulating RNA metabolism and stability within these cells, which is essential for proper germ cell development. While DND1 is not required for PGC migration to the gonads, DND1 is vital for their development, and mutations in DND1 can lead to germ cell loss and increased risk of testicular germ cell tumors, highlighting DND1′s potential involvement in tumorigenesis.

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DND1 Antibody (X22) References:

1. dead end, a novel vertebrate germ plasm component, is required for zebrafish primordial germ cell migration and survival.  |  Weidinger, G., et al. 2003. Curr Biol. 13: 1429-34. PMID: 12932328
2. The Ter mutation in the dead end gene causes germ cell loss and testicular germ cell tumours.  |  Youngren, KK., et al. 2005. Nature. 435: 360-4. PMID: 15902260
3. The role of dead-end in germ-cell tumor development.  |  Zhu, R., et al. 2007. Ann N Y Acad Sci. 1120: 181-6. PMID: 17905939
4. Analysis of the DND1 gene in men with sporadic and familial testicular germ cell tumors.  |  Linger, R., et al. 2008. Genes Chromosomes Cancer. 47: 247-52. PMID: 18069663
5. RNA-binding protein Dnd1 inhibits microRNA access to target mRNA.  |  Kedde, M., et al. 2007. Cell. 131: 1273-86. PMID: 18155131
6. Interplay between microRNAs and RNA-binding proteins determines developmental processes.  |  Kedde, M. and Agami, R. 2008. Cell Cycle. 7: 899-903. PMID: 18414021
7. Mouse apolipoprotein B editing complex 3 (APOBEC3) is expressed in germ cells and interacts with dead-end (DND1).  |  Bhattacharya, C., et al. 2008. PLoS One. 3: e2315. PMID: 18509452
8. A new inbred subline of mice (129-terSv) with a high incidence of spontaneous congenital testicular teratomas.  |  Stevens, LC. 1973. J Natl Cancer Inst. 50: 235-42. PMID: 4692863

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-DND1 Antibody (X22) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-DND1 Antibody (X22) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

DND1 Antibody (X22) Specifications

Alternate Product Name: DND1

Product Clone Name: X22

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 167-260

Epitope Target: DND1

Epitope Species: human

Product Reactivity/Detection: DND1

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP

Vialing Information: Each vial contains 100 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for DND1 Antibody (X22): N/A