DNASE1L1 Antibody (KK-M3): sc-134320

DNASE1L1 Antibody (KK-M3) is a mouse monoclonal IgG1 kappa light chain antibody that detects DNASE1L1 protein of human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-DNASE1L1 antibody (KK-M3) is available as a non-conjugated monoclonal isotype antibody. DNASE1L1, also known as deoxyribonuclease I-like 1, XIB, DNL1L, or DNASEX, is a 302 amino acid protein that plays a crucial role in DNA degradation, particularly during apoptosis, by mediating internucleosomal DNA fragmentation through catalytic activity. This function is vital for maintaining cellular homeostasis and preventing damaged DNA accumulation, which can lead to various diseases, including cancer. DNASE1L1 is predominantly localized in the endoplasmic reticulum and is expressed at high levels in cardiac and skeletal muscle, with lower expression in other tissues, highlighting importance in muscle physiology and development. The gene encoding DNASE1L1 is located on the X chromosome, which is significant as this location is involved in sex determination and is associated with several genetic disorders when abnormalities occur. DNASE1L1 (KK-M3) monoclonal antibody provides researchers with a valuable tool for studying this protein′s role in various biological processes and disease states.

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DNASE1L1 Antibody (KK-M3) References:

1. Molecular characterization of a novel endonuclease (Xib) and possible involvement in lysosomal glycogen storage disorders.  |  Malferrari, G., et al. 1999. Exp Mol Pathol. 66: 123-30. PMID: 10409440
2. Deletion polymorphism of DNASE1L1, an X-linked DNase I-like gene, in acid maltase deficiency disorders.  |  Malferrari, G., et al. 2001. Exp Mol Pathol. 70: 173-4. PMID: 11263960
3. Physical and biochemical properties of mammalian DNase X proteins: non-AUG translation initiation of porcine and bovine mRNAs for DNase X.  |  Shiokawa, D., et al. 2005. Biochem J. 392: 511-7. PMID: 16107205
4. Isolation, differential splicing and protein expression of a DNase on the human X chromosome.  |  Coy, JF., et al. 1996. Cell Death Differ. 3: 199-206. PMID: 17180083
5. A muscle-specific DNase I-like gene in human Xq28.  |  Parrish, JE., et al. 1995. Hum Mol Genet. 4: 1557-64. PMID: 8541839
6. Cloning of a gene encoding a DNase I-like endonuclease in the human Xq28 region.  |  Pergolizzi, R., et al. 1996. Gene. 168: 267-70. PMID: 8654957
7. Identification, localization, and expression of two novel human genes similar to deoxyribonuclease I.  |  Rodriguez, AM., et al. 1997. Genomics. 42: 507-13. PMID: 9205125

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-DNASE1L1 Antibody (KK-M3) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-DNASE1L1 Antibody (KK-M3) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

DNASE1L1 Antibody (KK-M3) Specifications

Alternate Product Name: DNASE1L1

Product Clone Name: KK-M3

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 18-303

Epitope Target: DNASE1L1

Epitope Species: human

Product Reactivity/Detection: DNASE1L1

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, ELISA

Vialing Information: Each vial contains 100 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for DNASE1L1 Antibody (KK-M3): N/A