Molecular structure of DNA-PK Inhibitor II, CAS Number: 154447-35-5
DNA-PK Inhibitor II (CAS 154447-35-5)
See product citations (6)
Alternate Names:
NU7026; 2-(Morpholin-4-yl)-benzo[h]chromen-4-one
Application:
DNA-PK Inhibitor II is an antiproliferative agent, and inhibitor of DNA-PK
CAS Number:
154447-35-5
Purity:
>98%
Molecular Weight:
281.31
Molecular Formula:
C17H15NO3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
DNA-PK inhibitor II, a cell-permeable compound, is shown to be a potent inhibitor of DNA repair enzymes. DNA-PK inhibition makes it potentially possible to make cell lines become more sensitive to ionizing radiation (IR) and a reduction of lethal damage recovery could be possible. DNA-PK inhibitor II treatment of cells is shown to inhibit IR-induced DNA double strand break repair.
DNA-PK Inhibitor II (CAS 154447-35-5) References
- 2,6-disubstituted pyran-4-one and thiopyran-4-one inhibitors of DNA-Dependent protein kinase (DNA-PK). | Hollick, JJ., et al. 2003. Bioorg Med Chem Lett. 13: 3083-6. PMID: 12941339
- Radiosensitization and DNA repair inhibition by the combined use of novel inhibitors of DNA-dependent protein kinase and poly(ADP-ribose) polymerase-1. | Veuger, SJ., et al. 2003. Cancer Res. 63: 6008-15. PMID: 14522929
- A novel DNA-dependent protein kinase inhibitor, NU7026, potentiates the cytotoxicity of topoisomerase II poisons used in the treatment of leukemia. | Willmore, E., et al. 2004. Blood. 103: 4659-65. PMID: 15010369
- Preclinical pharmacokinetics and metabolism of a novel prototype DNA-PK inhibitor NU7026. | Nutley, BP., et al. 2005. Br J Cancer. 93: 1011-8. PMID: 16249792
- Chlorambucil cytotoxicity in malignant B lymphocytes is synergistically increased by 2-(morpholin-4-yl)-benzo[h]chomen-4-one (NU7026)-mediated inhibition of DNA double-strand break repair via inhibition of DNA-dependent protein kinase. | Amrein, L., et al. 2007. J Pharmacol Exp Ther. 321: 848-55. PMID: 17351105
- Radio-sensitization of human leukaemic molt-4 cells by DNA-dependent protein kinase inhibitor, NU7026. | Tichý, A., et al. 2012. Acta Medica (Hradec Kralove). 55: 66-73. PMID: 23101268
- Inhibition of DNA-dependent protein kinase catalytic subunit by small molecule inhibitor NU7026 sensitizes human leukemic K562 cells to benzene metabolite-induced apoptosis. | You, H., et al. 2013. J Huazhong Univ Sci Technolog Med Sci. 33: 43-50. PMID: 23392706
- Effects of dna-dependent protein kinase inhibition by NU7026 on dna repair and cell survival in irradiated gastric cancer cell line N87. | Niazi, MT., et al. 2014. Curr Oncol. 21: 91-6. PMID: 24764698
- Combining carbon ion irradiation and non-homologous end-joining repair inhibitor NU7026 efficiently kills cancer cells. | Ma, H., et al. 2015. Radiat Oncol. 10: 225. PMID: 26553138
- DNA-Dependent Protein Kinase As Molecular Target for Radiosensitization of Neuroblastoma Cells. | Dolman, ME., et al. 2015. PLoS One. 10: e0145744. PMID: 26716839
- Suppressing the NHEJ pathway by DNA-PKcs inhibitor NU7026 prevents degradation of HBV cccDNA cleaved by CRISPR/Cas9. | Kostyushev, D., et al. 2019. Sci Rep. 9: 1847. PMID: 30755668
- DNA-dependent protein kinase: effect on DSB repair, G2/M checkpoint and mode of cell death in NSCLC cell lines. | Sak, A., et al. 2019. Int J Radiat Biol. 95: 1205-1219. PMID: 31287365
- A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002). | Vlahos, CJ., et al. 1994. J Biol Chem. 269: 5241-8. PMID: 8106507
Inhibitor of:
APLF, C9orf102, DNA pol θ, DNA-PK, EEPD1, EG240921, ELOF1, Etaa1, FAAP24, Histone H2AX, hPMS1, KILLIN, MRT-2, NBS1, NSE1, Rad50, RAD54L2, Rad57, RMI2, RNF168, and RNF8.Activator of:
53BP1, C17orf53, CCDC11, FANCM, Histone H2A.X, RHOBTB1, Rnr1, and XLF.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
DNA-PK Inhibitor II, 10 mg | sc-202143 | 10 mg | $155.00 | |||
DNA-PK Inhibitor II, 50 mg | sc-202143A | 50 mg | $660.00 |