Molecular structure of DNA Base Excision Repair Pathway Inhibitor, CAS Number: 6960-45-8
DNA Base Excision Repair Pathway Inhibitor Inhibitor (CAS 6960-45-8)
Alternate Names:
7-Nitroindole-2-carboxylic acid
Application:
DNA Base Excision Repair Pathway Inhibitor is a potent, nontoxic, and cell-permeable APE1 inhibitor
CAS Number:
6960-45-8
Purity:
≥95%
Molecular Weight:
206.15
Molecular Formula:
C9H6N2O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
DNA Base Excision Repair Pathway Inhibitor is a potent, nontoxic, specific, and cell-permeable DNA repair enzyme inhibitor. It may act to inhibit the 3#39-phosphodiesterase and 3#39-phosphatase activities of the Ref-1 (APE1) active site. Even at high concentrations, it is shown to have little effect on BamH1, topoisomerase I, restriction endonuclease, or endonuclease IV. Furthermore, this compound has demonstrated an ability to enhance the cytotoxicity of several DNA damaging agents such as temozolomide, Zeocin, MMS, and H202 in Hela, MDA-MB-231, and HT1080 cells.
DNA Base Excision Repair Pathway Inhibitor Inhibitor (CAS 6960-45-8) References
- Isolation of a small molecule inhibitor of DNA base excision repair. | Madhusudan, S., et al. 2005. Nucleic Acids Res. 33: 4711-24. PMID: 16113242
- Potent inhibition of human apurinic/apyrimidinic endonuclease 1 by arylstibonic acids. | Seiple, LA., et al. 2008. Mol Pharmacol. 73: 669-77. PMID: 18042731
- Going ape as an approach to cancer therapeutics. | Bapat, A., et al. 2009. Antioxid Redox Signal. 11: 651-68. PMID: 18715143
- Small-molecule inhibitors of proteins involved in base excision repair potentiate the anti-tumorigenic effect of existing chemotherapeutics and irradiation. | Reed, AM., et al. 2009. Future Oncol. 5: 713-26. PMID: 19519210
- Cross-talk-free dual-color fluorescence cross-correlation spectroscopy for the study of enzyme activity. | Lee, W., et al. 2010. Anal Chem. 82: 1401-10. PMID: 20073480
- Radiation resistance in glioma cells determined by DNA damage repair activity of Ape1/Ref-1. | Naidu, MD., et al. 2010. J Radiat Res. 51: 393-404. PMID: 20679741
- Molecular mechanisms of chemoresistance in osteosarcoma (Review). | He, H., et al. 2014. Oncol Lett. 7: 1352-1362. PMID: 24765137
- A specific DNA-nanoprobe for tracking the activities of human apurinic/apyrimidinic endonuclease 1 in living cells. | Zhai, J., et al. 2017. Nucleic Acids Res. 45: e45. PMID: 27923991
- Identification of New Potential APE1 Inhibitors by Pharmacophore Modeling and Molecular Docking. | Lee, IW., et al. 2017. Genomics Inform. 15: 147-155. PMID: 29307141
- Programming in situ accelerated DNA walkers in diffusion-limited microenvironments. | Chen, F., et al. 2019. Chem Sci. 10: 3103-3109. PMID: 30996893
- The multifunctional APE1 DNA repair-redox signaling protein as a drug target in human disease. | Caston, RA., et al. 2021. Drug Discov Today. 26: 218-228. PMID: 33148489
- The Role of 8-oxoG Repair Systems in Tumorigenesis and Cancer Therapy. | Li, C., et al. 2022. Cells. 11: PMID: 36497058
- Characterizing inhibitors of human AP endonuclease 1. | Pidugu, LS., et al. 2023. PLoS One. 18: e0280526. PMID: 36652434
Inhibitor of:
Ref-1.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
DNA Base Excision Repair Pathway Inhibitor, 1 g | sc-202588 | 1 g | $94.00 |