Molecular structure of DMPO, CAS Number: 3317-61-1
DMPO (CAS 3317-61-1)
See product citations (6)
Alternate Names:
5,5-Dimethyl-1-pyrroline-N-oxide; 2,2-Dimethyl-3,4-dihydro-2H-pyrrole 1-oxide
Application:
DMPO is a cell permeable hydrophillic spin trap agent for superoxide detection
CAS Number:
3317-61-1
Purity:
≥98%
Molecular Weight:
113.16
Molecular Formula:
C6H11NO
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
QUICK LINKS
Ordering Information
Product Citations
Description
Technical Information
Safety Information
SDS & Certificate of Analysis
DMPO is a used as a cell permeable hydrophilic spin trap for studies of superoxide, S-, O-, C- and N- centered free radicals. It has demonstrated neuroprotective properties. When lymphocytes were incubated in the presence of DMPO, DMPO decreased NiCl induced DNA damage.
DMPO (CAS 3317-61-1) References
- Metabolism of acetaldehyde to methyl and acetyl radicals: in vitro and in vivo electron paramagnetic resonance spin-trapping studies. | Nakao, LS., et al. 2000. Free Radic Biol Med. 29: 721-9. PMID: 11053773
- Free radicals-mediated induction of oxidized DNA bases and DNA-protein cross-links by nickel chloride. | Woźniak, K. and Błasiak, J. 2002. Mutat Res. 514: 233-43. PMID: 11815261
- Using anti-5,5-dimethyl-1-pyrroline N-oxide (anti-DMPO) to detect protein radicals in time and space with immuno-spin trapping. | Mason, RP. 2004. Free Radic Biol Med. 36: 1214-23. PMID: 15110386
- DMPO-OH radical formation from 5,5-dimethyl-1-pyrroline N-oxide (DMPO) in hot water. | Shoji, T., et al. 2007. Anal Sci. 23: 219-21. PMID: 17297236
- Immuno-spin trapping of protein and DNA radicals: 'tagging' free radicals to locate and understand the redox process. | Gomez-Mejiba, SE., et al. 2009. Free Radic Biol Med. 46: 853-65. PMID: 19159679
- Formation of artifactual DMPO-OH spin adduct in acid solutions containing nitrite ions. | Takayanagi, T., et al. 2017. Free Radic Res. 51: 739-748. PMID: 28817986
- Investigation on the Unexplored Photochemistry of 5,5-Dimethyl-1-pyrroline 1-Oxide (DMPO). | Sen, S., et al. 2019. J Phys Chem A. 123: 163-170. PMID: 30509064
- The effect of DMPO on the formation of hydroxyl radicals on the rutile TiO2(110) surface. | Lei, Y., et al. 2020. Phys Chem Chem Phys. 22: 13129-13135. PMID: 32490451
- NMDA-dependent superoxide production and neurotoxicity. | Lafon-Cazal, M., et al. 1993. Nature. 364: 535-7. PMID: 7687749
- Nitrone spin traps and a nitroxide antioxidant inhibit a common pathway of thymocyte apoptosis. | Slater, AF., et al. 1995. Biochem J. 306 (Pt 3): 771-8. PMID: 7702573
- The spin trapping of superoxide and hydroxyl free radicals with DMPO (5,5-dimethylpyrroline-N-oxide): more about iron. | Buettner, GR. 1993. Free Radic Res Commun. 19 Suppl 1: S79-87. PMID: 8282235
- Formation of spin trap adducts during the decomposition of peroxynitrite. | Gatti, RM., et al. 1998. Arch Biochem Biophys. 349: 36-46. PMID: 9439580
- Inducible nitric-oxide synthase generates superoxide from the reductase domain. | Xia, Y., et al. 1998. J Biol Chem. 273: 22635-9. PMID: 9712892
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
DMPO, 500 mg | sc-202587 | 500 mg | $214.00 | |||
DMPO, 1 g | sc-202587A | 1 g | $318.00 |