DMPO CAS: 3317-61-1
MF: C6H11NO
MW: 113.16
A cell permeable hydrophillic spin trap agent for superoxide detection.

DMPO (CAS 3317-61-1)

DMPO | CAS 3317-61-1 is rated 5.0 out of 5 by 1.
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Alternate Names: 5,5-Dimethyl-1-pyrroline-N-oxide; 2,2-Dimethyl-3,4-dihydro-2H-pyrrole 1-oxide
Application: DMPO is a cell permeable hydrophillic spin trap agent for superoxide detection
CAS Number: 3317-61-1
Purity: ≥98%
Molecular Weight: 113.16
Molecular Formula: C6H11NO
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).
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DMPO is a commonly used as a cell permeable hydrophilic spin trap for studies of superoxide, S-, O-, C- and N- centered free radicals. It has demonstrated neuroprotective properties. When lymphocytes were incubated in the presence of DMPO, DMPO decreased NiCl induced DNA damage.


References

1. Buettner, G.R. 1993. Free Radic. Res. Commun. 19: S79-S87. PMID: 8282235
2. Lafon-Cazal, M., et al. 1993. Nature. 364: 535-537. PMID: 7687749
3. Slater, A.F., et al. 1995. Biochem. J. 306: 771-778. PMID: 7702573
4. Gatti, R.M., et al. 1998. Arch. Biochem. Biophys. 349: 36-46. PMID: 9439580
5. Xia, Y., et al. 1998. J. Biol. Chem. 273: 22635-22639. PMID: 9712892
6. Nakao, L.S., et al. 2000. Free Radic. Biol. Med. 29: 721-729. PMID: 11053773
7. Woźniak, K., et al. 2002. Mutat. Res. 514: 233-243. PMID: 11815261
8. Gomez-Mejiba, S.E., et al. 2009. Free Radic. Biol. Med. 46: 853-865. PMID: 19159679

Physical State :
Low-Melting Solid
Solubility :
Soluble in water, ethanol (~42 mg/ml), methanol, DMSO (~42 mg/ml), and DMF (~42 mg/ml).
Storage :
Store at -20° C
Melting Point :
25-29° C (lit.)
Boiling Point :
75° C (lit.) at 4 mmHg
Density :
1.02 g/mL at 20° C (Predicted)
Refractive Index :
n20D 1.50
pK Values :
pKb: 2.47 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
1774
Merck Index :
14: 3393
MDL Number :
MFCD00005279
EC Number :
222-011-1
Beilstein Registry :
107603
SMILES :
CC1(CCC=[N+]1[O-])C

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Certificate of Analysis

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DMPO (CAS 3317-61-1) Product Citations

See how others have used DMPO (CAS 3317-61-1). Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 24074044  2013. J. Am. Chem. Soc. 135: 15923-32.

Citations 1 to 1 of 1 total
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Rated 5 out of 5 by from Various publications cite the use of DMPO Various publications cite the use of DMPO, a cell permeable hydrophilic spin trap, for studies of superoxide, S-, O-, C- and N- centered free radicals. -SCBT Publication Review
Date published: 2015-01-18
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