Molecular structure of DMNQ, CAS Number: 6956-96-3
DMNQ (CAS 6956-96-3)
Application:
DMNQ is a non-alkylating redox cycling quinone
CAS Number:
6956-96-3
Purity:
>99%
Molecular Weight:
218.2
Molecular Formula:
C12H10O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
DMNQ is a non-alkylating, adduct-forming, non-thiol, cell-permeable, redox cycling quinone. It can be used as the source of reactive oxidant species/oxidative stress to eliminate any mechanistic ambiguity in biological studies. It has also been reported to cause cell proliferation or necrotic or apoptotic cell death in a concentration-dependent manner.
DMNQ (CAS 6956-96-3) References
- Autoxidation of extracellular hydroquinones is a causative event for the cytotoxicity of menadione and DMNQ in A549-S cells. | Watanabe, N. and Forman, HJ. 2003. Arch Biochem Biophys. 411: 145-57. PMID: 12590933
- Imaging dynamic redox changes in mammalian cells with green fluorescent protein indicators. | Dooley, CT., et al. 2004. J Biol Chem. 279: 22284-93. PMID: 14985369
- Neural stem cells and cell death. | Ceccatelli, S., et al. 2004. Toxicol Lett. 149: 59-66. PMID: 15093249
- Enhancement of DMNQ-induced hepatocyte toxicity by cytochrome P450 inhibition. | Ishihara, Y., et al. 2006. Toxicol Appl Pharmacol. 214: 109-17. PMID: 16430935
- l-Serine protects mouse hippocampal neuronal HT22 cells against oxidative stress-mediated mitochondrial damage and apoptotic cell death. | Kim, KY., et al. 2019. Free Radic Biol Med. 141: 447-460. PMID: 31326607
- GSK3β is a key regulator of the ROS-dependent necrotic death induced by the quinone DMNQ. | Ciotti, S., et al. 2020. Cell Death Dis. 11: 2. PMID: 31919413
- Binding sites of quinones in photosynthetic bacterial reaction centers investigated by light-induced FTIR difference spectroscopy: binding of chainless symmetrical quinones to the QA site of Rhodobacter sphaeroides. | Breton, J., et al. 1994. Biochemistry. 33: 12405-15. PMID: 7918463
- Quinone-induced oxidative stress elevates glutathione and induces gamma-glutamylcysteine synthetase activity in rat lung epithelial L2 cells. | Shi, MM., et al. 1994. J Biol Chem. 269: 26512-7. PMID: 7929374
- Different prooxidant levels stimulate growth, trigger apoptosis, or produce necrosis of insulin-secreting RINm5F cells. The role of intracellular polyamines. | Dypbukt, JM., et al. 1994. J Biol Chem. 269: 30553-60. PMID: 7982974
- The relative importance of oxidative stress versus arylation in the mechanism of quinone-induced cytotoxicity to platelets. | Seung, SA., et al. 1998. Chem Biol Interact. 113: 133-44. PMID: 9717514
Inhibitor of:
NQO1.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
DMNQ, 10 mg | sc-202586 | 10 mg | $245.00 |