Date published: 2026-5-24

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DMEQ-TAD (CAS 132788-52-4)

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Alternate Names:
4-[2-(3,4-Dihydro-6,7-dimethoxy-4-methyl-3-oxo-2-quinoxalinyl)ethyl]-3H-1,2,4-triazole-3,5(4H)-dione
Application:
DMEQ-TAD is A reagent used in the fluorescence-labeling of Vitamin D
CAS Number:
132788-52-4
Molecular Weight:
345.31
Molecular Formula:
C15H15N5O5
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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DMEQ-TAD is a reagent in the fluorescence-labeling of Vitamin D and its use in assaying Vitamin D metabolites. DMEQ-TAD is a compound designed to function as a potent inhibitor of NF-κB activation. NF-κB (nuclear factor kappa-light-chain-enhancer of activated B cells) is a protein complex that plays a critical role in regulating the immune response, inflammation, and cell survival. DMEQ-TAD′s specificity and potency against NF-κB.


DMEQ-TAD (CAS 132788-52-4) References

  1. High levels of yessotoxin in mussels and presence of yessotoxin and homoyessotoxin in dinoflagellates of the Adriatic Sea.  |  Draisci, R., et al. 1999. Toxicon. 37: 1187-93. PMID: 10400302
  2. Fluorometric analysis of pectenotoxin-2 in microalgal samples by high performance liquid chromatography.  |  Sasaki, K., et al. 1999. Nat Toxins. 7: 241-6. PMID: 11122513
  3. Repeatability and validity of a fluorimetric HPLC method in the quantification of yessotoxin in blue mussels (Mytilus edulis) related to the mouse bioassay.  |  Ramstad, H., et al. 2001. Toxicon. 39: 1393-7. PMID: 11384729
  4. Fluorometric assay of 25-hydroxyvitamin D3 and 24R,25-dihydroxyvitamin D3 in plasma.  |  Shimizu, M., et al. 1992. Anal Biochem. 204: 258-64. PMID: 1443523
  5. Production and release of yessotoxins by the dinoflagellates Protoceratium reticulatum and Lingulodinium polyedrum in culture.  |  Paz, B., et al. 2004. Toxicon. 44: 251-8. PMID: 15302531
  6. Detection and identification of glycoyessotoxin A in a culture of the dinoflagellate Protoceratium reticulatum.  |  Paz, B., et al. 2006. Toxicon. 48: 611-9. PMID: 16920172
  7. Clinical utility of simultaneous quantitation of 25-hydroxyvitamin D and 24,25-dihydroxyvitamin D by LC-MS/MS involving derivatization with DMEQ-TAD.  |  Kaufmann, M., et al. 2014. J Clin Endocrinol Metab. 99: 2567-74. PMID: 24670084
  8. Effect of carbon chain length in acyl coenzyme A on the efficiency of enzymatic transformation of okadaic acid to 7-O-acyl okadaic acid.  |  Furumochi, S., et al. 2016. Bioorg Med Chem Lett. 26: 2992-2996. PMID: 27231127
  9. Serum 24,25-dihydroxyvitamin D3 response to native vitamin D2 and D3 Supplementation in patients with chronic kidney disease on hemodialysis.  |  Graeff-Armas, LA., et al. 2018. Clin Nutr. 37: 1041-1045. PMID: 28506446
  10. Elucidation of metabolic pathways of 25-hydroxyvitamin D3 mediated by CYP24A1 and CYP3A using Cyp24a1 knockout rats generated by CRISPR/Cas9 system.  |  Yasuda, K., et al. 2021. J Biol Chem. 296: 100668. PMID: 33865853
  11. Stability of sample extracts of vitamin D3 metabolites after chemical derivatization for LC-MS/MS analysis.  |  Alexandridou, A. and Volmer, DA. 2023. Anal Bioanal Chem. 415: 327-333. PMID: 36342509
  12. Fluorimetric assay of 1 alpha,25-dihydroxyvitamin D3 in human plasma.  |  Shimizu, M., et al. 1997. J Chromatogr B Biomed Sci Appl. 690: 15-23. PMID: 9106025
  13. Fluorometric measurement of yessotoxins in shellfish by high-pressure liquid chromatography.  |  Yasumoto, T. and Takizawa, A. 1997. Biosci Biotechnol Biochem. 61: 1775-7. PMID: 9362127
  14. High-performance liquid chromatographic separation of microcystins derivatized with a highly fluorescent dienophile.  |  Harada, K., et al. 1997. Nat Toxins. 5: 201-7. PMID: 9496379

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

DMEQ-TAD, 5 mg

sc-211369
5 mg
$312.00