DMEOB CAS: 40252-74-2
MF: C16H16N2O2
MW: 268.31
A negative allosteric modulator at mGluR-5.

DMEOB (CAS 40252-74-2)

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Application: DMEOB is a negative allosteric modulator at mGluR-5
CAS Number: 40252-74-2
Molecular Weight: 268.31
Molecular Formula: C16H16N2O2
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

DMEOB is a negative allosteric modulator at mGluR-5. DMEOB exhibits reversible noncompetitive inhibition of mGluR-5-mediated responses. In general, group I metabotropic glutamate receptors are coupled to Gq/11 and are activators of phospholipase C.


References

1. O'Brien, J.A., et al. 2003. Mol. Pharmacol. 64: 731-740. PMID: 12920211

Physical State :
Solid
Solubility :
Soluble in ethanol (100 mM), and DMSO (~28 mg/ml). Insoluble in water.
Storage :
Store at 4° C
Melting Point :
109.67° C (Predicted)
Boiling Point :
405.08° C at 760 mmHg (Predicted)
Density :
1.06 g/cm3 (Predicted)
Refractive Index :
n20D 1.54 (Predicted)
IC50 :
mGlu5-mediated responses: IC50 = 3 µM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
6891506
MDL Number :
MFCD01001892
SMILES :
COC1=CC=CC(=C1)/C=N/N=C/C2=CC(=CC=C2)OC

Download SDS (MSDS)

Certificate of Analysis

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