DMAB-anabaseine dihydrochloride (CAS 32013-69-7)
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DMAB-anabaseine dihydrochloride is a compound that functions as a potent and selective agonist at the α7 nicotinic acetylcholine receptor. It acts by binding to the receptor and activating it, leading to the opening of ion channels and the influx of calcium ions into the cell. This activation of the α7 nicotinic acetylcholine receptor may modulate neurotransmitter release, particularly enhancing the release of dopamine, glutamate, and GABA. In experimental applications, DMAB-anabaseine dihydrochloride is used to study the role of the α7 nicotinic acetylcholine receptor in various physiological and pathological processes. Its mechanism of action at the molecular level involves specific interactions with the receptor protein, leading to downstream signaling cascades and cellular responses. DMAB-anabaseine dihydrochloride serves as a useful tool for investigating the function and pharmacology of the α7 nicotinic acetylcholine receptor in diverse experimental applications.
DMAB-anabaseine dihydrochloride (CAS 32013-69-7) References
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- Pharmacological characterization of [(125)I]CHIBA-1006 binding, a new radioligand for α7 nicotinic acetylcholine receptors, to rat brain membranes. | Wu, J., et al. 2010. Brain Res. 1360: 130-7. PMID: 20816767
- Signals of vagal circuits engaging with AKT1 in α7 nAChR+CD11b+ cells lessen E. coli and LPS-induced acute inflammatory injury. | Zhao, C., et al. 2017. Cell Discov. 3: 17009. PMID: 28529765
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
DMAB-anabaseine dihydrochloride, 1 mg | sc-203568 | 1 mg | $377.00 |