Molecular structure of DM 235, CAS Number: 314728-85-3
DM 235 (CAS 314728-85-3)
Alternate Names:
1-(4-benzoylpiperazin-1-yl)propan-1-one; Sunifiram
Application:
DM 235 is a strong nootropic agent
CAS Number:
314728-85-3
Molecular Weight:
246.30
Molecular Formula:
C14H18N2O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Potent nootropic agent.
DM 235 (CAS 314728-85-3) References
- Molecular simplification of 1,4-diazabicyclo[4.3.0]nonan-9-ones gives piperazine derivatives that maintain high nootropic activity. | Manetti, D., et al. 2000. J Med Chem. 43: 4499-507. PMID: 11087574
- DM235 (sunifiram): a novel nootropic with potential as a cognitive enhancer. | Ghelardini, C., et al. 2002. Naunyn Schmiedebergs Arch Pharmacol. 365: 419-26. PMID: 12070754
- AMPA-receptor activation is involved in the antiamnesic effect of DM 232 (unifiram) and DM 235 (sunifiram). | Galeotti, N., et al. 2003. Naunyn Schmiedebergs Arch Pharmacol. 368: 538-45. PMID: 14600801
- Structure-activity relationship studies on unifiram (DM232) and sunifiram (DM235), two novel and potent cognition enhancing drugs. | Scapecchi, S., et al. 2004. Bioorg Med Chem. 12: 71-85. PMID: 14697772
- Pharmacological characterization of DM232 (unifiram) and DM235 (sunifiram), new potent cognition enhancers. | Romanelli, MN., et al. 2006. CNS Drug Rev. 12: 39-52. PMID: 16834757
- Design, synthesis and preliminary pharmacological evaluation of new analogues of DM232 (unifiram) and DM235 (sunifiram) as cognition modulators. | Martini, E., et al. 2008. Bioorg Med Chem. 16: 10034-42. PMID: 18954993
- Influence of ring size on the cognition-enhancing activity of DM235 and MN19, two potent nootropic drugs. | Guandalini, L., et al. 2012. Bioorg Med Chem Lett. 22: 1936-9. PMID: 22325944
- Novel nootropic drug sunifiram improves cognitive deficits via CaM kinase II and protein kinase C activation in olfactory bulbectomized mice. | Moriguchi, S., et al. 2013. Behav Brain Res. 242: 150-7. PMID: 23295391
- Novel nootropic drug sunifiram enhances hippocampal synaptic efficacy via glycine-binding site of N-methyl-D-aspartate receptor. | Moriguchi, S., et al. 2013. Hippocampus. 23: 942-51. PMID: 23733502
- Piperazines as nootropic agents: New derivatives of the potent cognition-enhancer DM235 carrying hydrophilic substituents. | Martino, MV., et al. 2017. Bioorg Med Chem. 25: 1795-1803. PMID: 28238510
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
DM 235, 5 mg | sc-300499 | 5 mg | $54.00 |