Dlx-5 Antibody (H-4): sc-398150

Dlx-5 Antibody (H-4) is a mouse monoclonal IgM antibody that detects Dlx-5 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-Dlx-5 antibody (H-4) is available as the non-conjugated form. Dlx-5 (H-4) antibody recognizes a protein that plays a crucial role in craniofacial skeleton development and influences differentiation of various structures within and between teeth, making Dlx-5 essential for proper morphogenesis and patterning during embryonic development. Dlx-5 belongs to the Dlx gene family, which consists of six homeobox-containing genes highly conserved across species and known to influence craniofacial structures and limb formation development. Dlx-5 (H-4) monoclonal antibody targets a protein primarily localized in the nucleus, where Dlx-5 activates transcription, though Dlx-5 can also be found in the cytoplasm, indicating multiple roles in cellular processes. Precise regulation of Dlx-5 expression is vital, as dysregulation can lead to developmental abnormalities, underscoring Dlx-5′s importance in both normal development and potential pathologies.

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Dlx-5 Antibody (H-4) References:

1. Expression of DLX5 during human embryonic craniofacial development.  |  Davideau, JL., et al. 1999. Mech Dev. 81: 183-6. PMID: 10330497
2. Dlx5 regulates regional development of the branchial arches and sensory capsules.  |  Depew, MJ., et al. 1999. Development. 126: 3831-46. PMID: 10433912
3. DLX-1, DLX-2, and DLX-5 expression define distinct stages of basal forebrain differentiation.  |  Eisenstat, DD., et al. 1999. J Comp Neurol. 414: 217-37. PMID: 10516593
4. Comparative study of MSX-2, DLX-5, and DLX-7 gene expression during early human tooth development.  |  Davideau, JL., et al. 1999. Pediatr Res. 46: 650-6. PMID: 10590019
5. Roles for Msx and Dlx homeoproteins in vertebrate development.  |  Bendall, AJ. and Abate-Shen, C. 2000. Gene. 247: 17-31. PMID: 10773441
6. Multiple functions of Dlx genes.  |  Merlo, GR., et al. 2000. Int J Dev Biol. 44: 619-26. PMID: 11061425
7. Gene expression of runx2, Osterix, c-fos, DLX-3, DLX-5, and MSX-2 in dental follicle cells during osteogenic differentiation in vitro.  |  Morsczeck, C. 2006. Calcif Tissue Int. 78: 98-102. PMID: 16467978
8. The Evf-2 noncoding RNA is transcribed from the Dlx-5/6 ultraconserved region and functions as a Dlx-2 transcriptional coactivator.  |  Feng, J., et al. 2006. Genes Dev. 20: 1470-84. PMID: 16705037
9. BRONJ-related jaw bone is associated with increased Dlx-5 and suppressed osteopontin-implication in the site-specific alteration of angiogenesis and bone turnover by bisphosphonates.  |  Wehrhan, F., et al. 2015. Clin Oral Investig. 19: 1289-98. PMID: 25467232
10. Expression of Dlx-5 and Msx-1 in Craniofacial Skeletons and Ilia of Rats Treated With Zoledronate.  |  Xuan, B., et al. 2017. J Oral Maxillofac Surg. 75: 994.e1-994.e9. PMID: 28153754
11. Dlx and other homeobox genes in the morphological development of the dentition.  |  Weiss, KM., et al. 1995. Connect Tissue Res. 32: 35-40. PMID: 7554933
12. Stage-specific expression of Dlx-5 during osteoblast differentiation: involvement in regulation of osteocalcin gene expression.  |  Ryoo, HM., et al. 1997. Mol Endocrinol. 11: 1681-94. PMID: 9328350

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Dlx-5 Antibody (H-4) has 2 citations in a variety of scientific publications.

Primary antibodies like Anti-Dlx-5 Antibody (H-4) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Dlx-5 Antibody (H-4) Specifications

Alternate Product Name: Dlx-5

Product Clone Name: H-4

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgM kappa light chain

Amino Acids: 98-127

Epitope Target: Dlx-5

Epitope Species: human

Product Reactivity/Detection: Dlx-5

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgM kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 2 citations in various scientific publications

Available Conjugates/Forms for Dlx-5 Antibody (H-4): P: Blocking Peptide, X: TransCruz Reagent