Dlx-1 Antibody (F-16): sc-81959

Dlx-1 Antibody (F-16) is a mouse monoclonal IgG2a kappa light chain antibody that detects Dlx-1 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-Dlx-1 antibody (F-16) is available as the non-conjugated form. Dlx-1, also known as distal-less homeobox 1, is a crucial 255 amino acid transcription factor that plays a significant role in the differentiation of progenitor cells into GABAergic neurons, which are essential for inhibitory signaling in the central nervous system. Dlx-1 is part of the Dlx gene family, which is highly conserved and influences various developmental processes, including the patterning of craniofacial structures and the differentiation of dental tissues. Dlx-1 is expressed in specific regions during development, including the craniofacial primordia and the basal telencephalon, where expression patterns are vital for proper morphogenesis and histogenesis. Dlx-1′s ability to regulate transcriptional hierarchies is particularly important, as this determines the fate of progenitor cells, influencing whether they develop into neurons or oligodendrocytes. This regulatory function underscores Dlx-1′s importance in neurodevelopment and potential implications in understanding developmental disorders and neurogenesis.

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Dlx-1 Antibody (F-16) References:

1. Expression of DLX5 during human embryonic craniofacial development.  |  Davideau, JL., et al. 1999. Mech Dev. 81: 183-6. PMID: 10330497
2. Dlx5 regulates regional development of the branchial arches and sensory capsules.  |  Depew, MJ., et al. 1999. Development. 126: 3831-46. PMID: 10433912
3. DLX-1, DLX-2, and DLX-5 expression define distinct stages of basal forebrain differentiation.  |  Eisenstat, DD., et al. 1999. J Comp Neurol. 414: 217-37. PMID: 10516593
4. Roles for Msx and Dlx homeoproteins in vertebrate development.  |  Bendall, AJ. and Abate-Shen, C. 2000. Gene. 247: 17-31. PMID: 10773441
5. Multiple functions of Dlx genes.  |  Merlo, GR., et al. 2000. Int J Dev Biol. 44: 619-26. PMID: 11061425
6. Dlx1 and Dlx2 control neuronal versus oligodendroglial cell fate acquisition in the developing forebrain.  |  Petryniak, MA., et al. 2007. Neuron. 55: 417-33. PMID: 17678855
7. Dlx and other homeobox genes in the morphological development of the dentition.  |  Weiss, KM., et al. 1995. Connect Tissue Res. 32: 35-40. PMID: 7554933

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Dlx-1 Antibody (F-16) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-Dlx-1 Antibody (F-16) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Dlx-1 Antibody (F-16) Specifications

Alternate Product Name: Dlx-1

Product Clone Name: F-16

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 152-256

Epitope Target: Dlx-1

Epitope Species: human

Product Reactivity/Detection: Dlx-1

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 100 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for Dlx-1 Antibody (F-16): N/A