Molecular structure of DL-threo-PDMP, Hydrochloride, CAS Number: 80938-69-8
DL-threo-PDMP, Hydrochloride (CAS 80938-69-8)
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Alternate Names:
(±)-threo-1-Phenyl-2-decanoylamino-3-morpholino-1-propanol hydrochloride
Application:
DL-threo-PDMP, Hydrochloride is a potent and competitive inhibitor of glucosyltransferase
CAS Number:
80938-69-8
Purity:
≥98%
Molecular Weight:
427.02
Molecular Formula:
C23H38N2O3•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
DL-threo-PDMP, Hydrochloride is a PDMP which closely resembles the natural sphingolipid substrate of brain glucosyltransferase and acts as a potent and competitive inhibitor of this enzyme. Blocks the outgrowth of neurites and inhibits glycolipid synthesis in cultured NIH/3T3 cells. DL-threo-PDMP, Hydrochloride is an inhibitor of UGCG (Glucosylceramide synthase).
DL-threo-PDMP, Hydrochloride (CAS 80938-69-8) References
- P-glycoprotein is implicated in the inhibition of ceramide-induced apoptosis in TF-1 acute myeloid leukemia cells by modulation of the glucosylceramide synthase pathway. | Turzanski, J., et al. 2005. Exp Hematol. 33: 62-72. PMID: 15661399
- Cholera toxin B-subunit prevents activation and proliferation of human CD4+ T cells by activation of a neutral sphingomyelinase in lipid rafts. | Rouquette-Jazdanian, AK., et al. 2005. J Immunol. 175: 5637-48. PMID: 16237053
Inhibitor of:
UGCG.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
DL-threo-PDMP, Hydrochloride, 50 mg | sc-203030 | 50 mg | $270.00 |