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DL-Isocitric acid trisodium salt (CAS 1637-73-6)

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Alternate Names:
threo-DsLs-Isocitric acid trisodium salt
Application:
DL-Isocitric acid trisodium salt is protonated isocitrate, useful as a marker for determining isocitrate composition
CAS Number:
1637-73-6
Purity:
≥93%
Molecular Weight:
258.07
Molecular Formula:
C6H5O7Na3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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DL-Isocitric acid trisodium salt is the protonated form of isocitrate, a substrate in the citric acid cycle. Researchers use it to investigate the regulation of this metabolic pathway and how it contributes to energy production and cellular function. It is also useful as a marker for determining the composition of isocitrates in fruit products, including fruit juices. Additionally, DL-Isocitric acid trisodium salt is a natural antioxidant used in food science research.


DL-Isocitric acid trisodium salt (CAS 1637-73-6) References

  1. Evaluation of rat hepatic 2E1 activity in function of age, sex and inducers: choice of an experimental model capable of testing the hepatotoxicity of low molecular weight compounds.  |  Morel, G., et al. 1999. Toxicol Lett. 106: 171-80. PMID: 10403661
  2. Fumaric acid: an overlooked form of fixed carbon in Arabidopsis and other plant species.  |  Chia, DW., et al. 2000. Planta. 211: 743-51. PMID: 11089689
  3. Automated software-guided identification of new buspirone metabolites using capillary LC coupled to ion trap and TOF mass spectrometry.  |  Fandiño, AS., et al. 2006. J Mass Spectrom. 41: 248-55. PMID: 16421870
  4. In vitro metabolism of the opioid tilidine and interaction of tilidine and nortilidine with CYP3A4, CYP2C19, and CYP2D6.  |  Weiss, J., et al. 2008. Naunyn Schmiedebergs Arch Pharmacol. 378: 275-82. PMID: 18516595
  5. An automated, high-throughput, 384 well Cytochrome P450 cocktail IC50 assay using a rapid resolution LC-MS/MS end-point.  |  Youdim, KA., et al. 2008. J Pharm Biomed Anal. 48: 92-9. PMID: 18584988
  6. Development of an in vitro drug-drug interaction assay to simultaneously monitor five cytochrome P450 isoforms and performance assessment using drug library compounds.  |  Zientek, M., et al. 2008. J Pharmacol Toxicol Methods. 58: 206-14. PMID: 18634893
  7. Enantioseparation of DL-isocitric acid by a chiral ligand exchange CE with Ni(II)-D-quinic acid system.  |  Kodama, S., et al. 2010. Electrophoresis. 31: 3586-91. PMID: 20925051
  8. Ultrastructural effects of Nifurtimox on rat adrenal cortex related to reductive biotransformation.  |  de Castro, CR., et al. 1990. Exp Mol Pathol. 52: 98-108. PMID: 2106446
  9. Analysis of organic acids in fruit juices by liquid chromatography-mass spectrometry: an enhanced tool for authenticity testing.  |  Ehling, S. and Cole, S. 2011. J Agric Food Chem. 59: 2229-34. PMID: 21361392
  10. In vitro identification of the cytochrome P450 isozymes involved in the N-demethylation of the active opioid metabolite nortilidine to bisnortilidine.  |  Wustrow, I., et al. 2012. Naunyn Schmiedebergs Arch Pharmacol. 385: 633-9. PMID: 22349139
  11. Identification of a novel inhibitor of isocitrate lyase as a potent antitubercular agent against both active and non-replicating Mycobacterium tuberculosis.  |  Liu, Y., et al. 2016. Tuberculosis (Edinb). 97: 38-46. PMID: 26980494
  12. Studies on the NAD-specific isocitrate dehydrogenase from baker's yeast.  |  Cennamo, C., et al. 1965. Biochim Biophys Acta. 110: 195-7. PMID: 4286144
  13. Effect of thioacetamide-induced hepatic necrosis on the regioselective metabolism of S-warfarin by rat liver mixed-function oxidase enzymes.  |  Obaseki, AO., et al. 1983. Biochem Pharmacol. 32: 2385-91. PMID: 6615541
  14. Liver nuclear ethanol metabolizing systems (NEMS) producing acetaldehyde and 1-hydroxyethyl free radicals.  |  Castro, GD., et al. 1998. Toxicology. 129: 137-44. PMID: 9772092

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

DL-Isocitric acid trisodium salt, 1 g

sc-214940
1 g
$114.00

DL-Isocitric acid trisodium salt, 5 g

sc-214940A
5 g
$316.00

DL-Isocitric acid trisodium salt, 10 g

sc-214940B
10 g
$573.00

DL-Isocitric acid trisodium salt, 25 g

sc-214940C
25 g
$995.00

DL-Isocitric acid trisodium salt, 50 g

sc-214940E
50 g
$1769.00

DL-Isocitric acid trisodium salt, 100 g

sc-214940D
100 g
$2705.00