Date published: 2025-9-5

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DL-Homocysteine (CAS 454-29-5)

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Alternate Names:
2-Amino-4-mercaptobutyric acid
Application:
DL-Homocysteine is a potential marker for tumor cell growth
CAS Number:
454-29-5
Purity:
>95%
Molecular Weight:
135.18
Molecular Formula:
C4H9NO2S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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DL-Homocysteine (DLHC), a variant of homocysteine, can adjust homocysteine levels within cells, applicable to both living organisms and controlled lab environments. Research involving DL-Homocysteine spans across various biological processes, including cell growth, programmed cell death, and the body′s response to oxidative stress. It is thought to bind to and inhibit enzymes responsible for homocysteine metabolism and to interact with specific proteins and lipids, potentially influencing their functions.


DL-Homocysteine (CAS 454-29-5) References

  1. The direct electrochemistry of myoglobin at a DL-homocysteine self-assembled gold electrode.  |  Zhang, HM. and Li, NQ. 2001. Bioelectrochemistry. 53: 97-101. PMID: 11206930
  2. Occurrence of transsulfuration in synthesis of L-homocysteine in an extremely thermophilic bacterium, Thermus thermophilus HB8.  |  Yamagata, S., et al. 2001. J Bacteriol. 183: 2086-92. PMID: 11222609
  3. Homocysteine induces expression and secretion of monocyte chemoattractant protein-1 and interleukin-8 in human aortic endothelial cells: implications for vascular disease.  |  Poddar, R., et al. 2001. Circulation. 103: 2717-23. PMID: 11390343
  4. Dual effect of DL-homocysteine and S-adenosylhomocysteine on brain synthesis of the glutamate receptor antagonist, kynurenic acid.  |  Luchowska, E., et al. 2005. J Neurosci Res. 79: 375-82. PMID: 15605380
  5. Are STATS arginine-methylated?  |  Komyod, W., et al. 2005. J Biol Chem. 280: 21700-5. PMID: 15826948
  6. Homocysteine, a risk factor for atherosclerosis, biphasically changes the endothelial production of kynurenic acid.  |  Stazka, J., et al. 2005. Eur J Pharmacol. 517: 217-23. PMID: 15961072
  7. Homocysteine at pathophysiologic concentrations activates human monocyte and induces cytokine expression and inhibits macrophage migration inhibitory factor expression.  |  Su, SJ., et al. 2005. Nutrition. 21: 994-1002. PMID: 16157236
  8. Effect of L-arginine on asymmetric dimethylarginine (ADMA) or homocysteine-accelerated endothelial cell aging.  |  Scalera, F., et al. 2006. Biochem Biophys Res Commun. 345: 1075-82. PMID: 16713997
  9. Role of NMDA receptor in homocysteine-induced activation of mitogen-activated protein kinase and phosphatidyl inositol 3-kinase pathways in cultured human vascular smooth muscle cells.  |  Doronzo, G., et al. 2010. Thromb Res. 125: e23-32. PMID: 19766294
  10. Interactions Between Nuclear Receptor SHP and FOXA1 Maintain Oscillatory Homocysteine Homeostasis in Mice.  |  Tsuchiya, H., et al. 2015. Gastroenterology. 148: 1012-1023.e14. PMID: 25701738
  11. Effects of homocysteine and its related compounds on oxygen consumption of the rat heart tissue homogenate: the role of different gasotransmitters.  |  Uzelac, JJ., et al. 2018. Mol Cell Biochem. 444: 143-148. PMID: 29188533
  12. Structure and dynamics of a dl-homocysteine functionalized fullerene-C60-gold nanocomposite: a femtomolar l-histidine sensor.  |  Sutradhar, S., et al. 2017. J Mater Chem B. 5: 5835-5844. PMID: 32264216
  13. Simultaneous determination of DL-cysteine, DL-homocysteine, and glutathione in saliva and urine by UHPLC-Q-Orbitrap HRMS: Application to studies of oxidative stress.  |  Ma, Q., et al. 2021. J Pharm Biomed Anal. 196: 113939. PMID: 33578266
  14. Toward Food Freshness Monitoring: Coordination Binding-Based Colorimetric Sensor Array for Sulfur-Containing Amino Acids.  |  Lyu, X., et al. 2021. Front Chem. 9: 685783. PMID: 34222197

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

DL-Homocysteine, 10 mg

sc-214939
10 mg
$40.00

DL-Homocysteine, 100 mg

sc-214939B
100 mg
$50.00

DL-Homocysteine, 1 g

sc-214939A
1 g
$95.00

What solution do you suggest to dissolve DL-Homocysteine in for a 1M stock solution?

Asked by: charnich94
Thank you for your question. In order to provide you with the best solution, we would need more information about your intended research application with this chemical. Please contact our Technical Service Department and we can help provide you with more details about the solubility of this chemical. Please call us toll-free at (800) 457-3801 option 2, e-mail <scbt@scbt.com>, or use the live chat on our website.
Answered by: Technical Support
Date published: 2017-08-29

What is the appearance of the compound?

Asked by: two2igm05
Thank you for your question. DL-Homocysteine, sc-214939, is in white powder form.
Answered by: Chemical Support 4
Date published: 2017-04-20
  • y_2025, m_8, d_27, h_5CST
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Rated 5 out of 5 by from Various publications cite the use of DLVarious publications cite the use of DL-Homocysteine as a potential marker for tumor cell growth. -SCBT Publication Review
Date published: 2015-05-19
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DL-Homocysteine is rated 5.0 out of 5 by 1.
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