DL-Dithiothreitol-d10 (CAS 302912-05-6)
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DL-Dithiothreitol-d10, often used in research applications, primarily functions as a reducing agent in biochemical and molecular biology experiments. It plays a significant role in the denaturation of proteins by reducing disulfide bonds, thus facilitating the analysis of protein structure and function. In molecular biology, DL-Dithiothreitol-d10 is utilized to maintain the reduced state of thiol groups, which is essential in the prevention of the re-formation of disulfide bonds during protein folding studies. Furthermore, it is used in the preparation of samples for electrophoresis, ensuring that proteins remain in a state that allows for proper migration and characterization. Additionally, its deuterated form is particularly useful in nuclear magnetic resonance (NMR) spectroscopy, as it provides a non-exchanging hydrogen environment that is beneficial for studying the structure of proteins and nucleic acids.
DL-Dithiothreitol-d10 (CAS 302912-05-6) References
- The RRM domain of poly(A)-specific ribonuclease has a noncanonical binding site for mRNA cap analog recognition. | Nagata, T., et al. 2008. Nucleic Acids Res. 36: 4754-67. PMID: 18641416
- Structural basis for the interaction between the first SURP domain of the SF3A1 subunit in U2 snRNP and the human splicing factor SF1. | Nameki, N., et al. 2022. Protein Sci. 31: e4437. PMID: 36173164
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
DL-Dithiothreitol-d10, 500 mg | sc-300494 | 500 mg | $1002.00 |