Molecular structure of DL-AP7, CAS Number: 78966-69-5
DL-AP7 (CAS 78966-69-5)
Alternate Names:
DL-2-Amino-7-phosphonoheptanoic acid
Application:
DL-AP7 is a potent NMDA receptor antagonist
CAS Number:
78966-69-5
Purity:
≥97%
Molecular Weight:
225.2
Molecular Formula:
C7H16NO5P
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
DL-AP7 is a competitive antagonist of the ionotropic glutamate receptor, NMDA. Studies indicate that the S1 and S2 domains of the NMDA receptor are essential in DL-AP7 and other related antagonists to bind to the receptor. In addition, the positively charged Lys residues at the second interaction site and Arg at the fourth site are key factors in ligand binding. The NMDA receptor is unique in that it requires binding of two ligands, glutamate and glycine to become activated. As a result of its inhibitory affects, DL-AP7 is an ideal tool in studying signaling pathways and ion flow through the NMDA receptor.
DL-AP7 (CAS 78966-69-5) References
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- Central mechanism of the cardiovascular responses caused by L-proline microinjected into the paraventricular nucleus of the hypothalamus in unanesthetized rats. | Lopes-Azevedo, S., et al. 2016. Brain Res. 1652: 43-52. PMID: 27693394
- Agonists, antagonists and modulators of excitatory amino acid receptors in the guinea-pig myenteric plexus. | Luzzi, S., et al. 1988. Br J Pharmacol. 95: 1271-7. PMID: 2905914
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- Glutamatergic, GABAergic, and endocannabinoid neurotransmissions within the dorsal hippocampus modulate the cardiac baroreflex function in rats. | Ferreira-Junior, NC., et al. 2018. Pflugers Arch. 470: 395-411. PMID: 29143219
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Inhibitor of:
NMDA.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
DL-AP7, 5 mg | sc-203028 | 5 mg | $57.00 |