DL-α-Difluoromethylornithine hydrochloride (CAS 68278-23-9)
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DL-α-Difluoromethylornithine hydrochloride is widely used in biochemical research, particularly in studies focused on enzyme inhibition. This chemical serves as an irreversible inhibitor of ornithine decarboxylase, an enzyme that plays a critical role in polyamine synthesis. Because of this inhibitory action, DL-α-Difluoromethylornithine hydrochloride is instrumental in research exploring cell growth and differentiation, as polyamines are vital for these cellular processes. Additionally, it is employed in investigations into the mechanisms of programmed cell death, or apoptosis, due to its impact on cellular polyamine levels. The chemical′s role in modulating polyamine content also makes it useful in studying the cellular response to oxidative stress and the regulation of ion channels.
DL-α-Difluoromethylornithine hydrochloride (CAS 68278-23-9) References
- alpha-difluoromethylornithine induces apoptosis as well as anti-angiogenesis in the inhibition of tumor growth and metastasis in a human gastric cancer model. | Takahashi, Y., et al. 2000. Int J Cancer. 85: 243-7. PMID: 10629084
- A quantitative angiogenesis model for efficacy testing of chemopreventive agents. | Sharma, S., et al. 2001. Anticancer Res. 21: 3829-37. PMID: 11911254
- Tumor angiogenesis and polyamines: alpha-difluoromethylornithine, an irreversible inhibitor of ornithine decarboxylase, inhibits B16 melanoma-induced angiogenesis in ovo and the proliferation of vascular endothelial cells in vitro. | Takigawa, M., et al. 1990. Cancer Res. 50: 4131-8. PMID: 1693880
- Polyamines prevent DFMO-mediated inhibition of angiogenesis. | Jasnis, MA., et al. 1994. Cancer Lett. 79: 39-43. PMID: 7514492
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
DL-α-Difluoromethylornithine hydrochloride, 10 mg | sc-252762A | 10 mg | $82.00 | |||
DL-α-Difluoromethylornithine hydrochloride, 25 mg | sc-252762 | 25 mg | $173.00 | |||
DL-α-Difluoromethylornithine hydrochloride, 50 mg | sc-252762B | 50 mg | $275.00 |