DL-α-Difluoromethylornithine hydrochloride inhibits polyamine biosynthesis by selective, irreversible inhibition of ornithine decarboxylase (ODC). DMFO hydrochloride is a chemoprotective agent that blocks angiogenesis.
1. Takigawa, M., et al., 1990. Tumor angiogenesis and polyamines: alpha-difluoromethylornithine, an irreversible inhibitor of ornithine decarboxylase, inhibits B16 melanoma-induced angiogenesis in ovo and the proliferation of vascular endothelial cells in vitro. Cancer research. 50(13): 4131-8. PMID: 1693880
2. Jasnis, M A., et al., 1994. Polyamines prevent DFMO-mediated inhibition of angiogenesis. Cancer letters. 79(1): 39-43. PMID: 7514492
3. Takahashi, Y., et al., 2000. alpha-difluoromethylornithine induces apoptosis as well as anti-angiogenesis in the inhibition of tumor growth and metastasis in a human gastric cancer model. International journal of cancer. Journal international du cancer. 85(2): 243-7. PMID: 10629084
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See how others have used DL-alpha-Difluoromethylornithine hydrochloride (CAS 68278-23-9). Click on the entry to view the PubMed entry .
PMID: # 31164374 Chalishazar, MD.|Wait, SJ.|Huang, F.|Ireland, AS.|Mukhopadhyay, A.|Lee, Y.|Schuman, SS.|Guthrie, MR.|Berrett, KC.|Vahrenkamp, JM.|Hu, Z.|Kudla, M.|Modzelewska, K.|Wang, G.|Ingolia, NT.|Gertz, J.|Lum, DH.|Cosulich, SC.|Bomalaski, JS.|DeBerardinis, RJ.|Oliver, TG.| et al. 2019. Clin. Cancer Res. 25: 5107-5121.
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