DL-2-Amino-3-phosphonopropionic acid (AP3) (CAS 20263-06-3)
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DL-2-Amino-3-phosphonopropionic acid (AP3), a racemic preparation of D-2-Amino-3-phosphonopropionic acid and L-2-Amino-3-phosphonopropionic acid, is an inhibitor of phosphoserine phosphatase and an antagonist of the receptor mGluR(metabotropic glutamate receptor), blocking phosphoinositide turnover mediated by the mGluR. D-2-Amino-3-phosphonopropionic acid demonstrates more potent inhibition of phosphoserine phosphatase than L-2-Amino-3-phosphonopropionic acid, and D-2-Amino-3-phosphonopropionic acid is specifically active at phosphoserine phosphatase while L-2-Amino-3-phosphonopropionic acid produces mGluR antagonism with similar potency to its inhibition of phosphoserine phosphatase. L-2-Amino-3-phosphonopropionic acid is described to antagonize the metabotropic Ca2+ mobilizing effects of the mGluR agonist Trans-ACPD (sc-202367) while D-2-Amino-3-phosphonopropionic acid shows no such antagonism.
DL-2-Amino-3-phosphonopropionic acid (AP3) (CAS 20263-06-3) References
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Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
DL-2-Amino-3-phosphonopropionic acid (AP3), 100 mg | sc-200433 | 100 mg | $119.00 |