Dkk-2 Antibody (183D2D): sc-517634

Dkk-2 Antibody (183D2D) is a mouse monoclonal IgG1 kappa light chain antibody that detects Dkk-2 protein of mouse, rat, and human origin by western blotting (WB). Anti-Dkk-2 antibody (183D2D) is available as a non-conjugated format, providing researchers with a reliable tool for studying this important protein. Dkk-2, or Dickkopf-2, plays a crucial role in regulating Wnt signaling, which is essential for various developmental processes, including embryogenesis and central nervous system formation. Dkk-2 is secreted and consists of 259 amino acids, featuring an N-terminal signal peptide and two conserved cysteine-rich domains separated by a linker region. Dkk-2′s structure is significant because cysteine-rich domains are critical for interaction with the Wnt pathway, allowing effective inhibition of Wnt signaling by binding to Frizzled receptors. This inhibition is vital for maintaining proper cellular functions and ensuring regulated developmental processes. Anti-Dkk-2 antibody (183D2D) helps researchers gain insights into Wnt signaling mechanisms and their implications in developmental biology and disease states.

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Dkk-2 Antibody (183D2D) References:

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