Divinyl sulfone (CAS 77-77-0)
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Divinyl sulfone is a chemical crosslinker known for its ability to react with nucleophilic groups in proteins, such as amino, hydroxyl, and thiol groups, forming stable covalent bonds. It is used to explore protein-protein interactions and analyze the structure-function relationships within proteins. Its crosslinking ability can stabilize complexes for analysis by various biochemical methods, including mass spectrometry and crystallography. In cell studies, it can immobilize enzymes or other proteins on surfaces, facilitating the analysis of biochemical pathways and interactions. Additionally, divinyl sulfone′s reactivity can be employed in the modification of biomaterials for tissue engineering applications, where it helps in creating scaffolds that interact with biological molecules. Its use extends to creating controlled-release systems where the release of bioactive molecules is triggered by environmental cues.
Divinyl sulfone (CAS 77-77-0) References
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- Relationship between structure and cytocompatibility of divinyl sulfone cross-linked hyaluronic acid. | Lai, JY. 2014. Carbohydr Polym. 101: 203-12. PMID: 24299766
- Simple method for Shiga toxin 2e purification by affinity chromatography via binding to the divinyl sulfone group. | Arimitsu, H., et al. 2013. PLoS One. 8: e83577. PMID: 24340102
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- Amino acid-based anti-fouling functionalization of silica nanoparticles using divinyl sulfone. | Wang, H., et al. 2016. Acta Biomater. 40: 273-281. PMID: 27032480
- Characterization of the Physicochemical Properties of β-Cyclodextrin-Divinyl Sulfone Polymer Carrier-Bile Acid Systems. | Mohamed, MH., et al. 2017. Mol Pharm. 14: 2616-2623. PMID: 28294623
- Chitosan activated with divinyl sulfone: a new heterofunctional support for enzyme immobilization. Application in the immobilization of lipase B from Candida antarctica. | Pinheiro, BB., et al. 2019. Int J Biol Macromol. 130: 798-809. PMID: 30817969
- A new heterofunctional support for enzyme immobilization: PEI functionalized Fe3O4 MNPs activated with divinyl sulfone. Application in the immobilization of lipase from Thermomyces lanuginosus. | Bezerra, RM., et al. 2020. Enzyme Microb Technol. 138: 109560. PMID: 32527529
- The combination of covalent and ionic exchange immobilizations enables the coimmobilization on vinyl sulfone activated supports and the reuse of the most stable immobilized enzyme. | Arana-Peña, S., et al. 2022. Int J Biol Macromol. 199: 51-60. PMID: 34973984
- Water as a monomer: synthesis of an aliphatic polyethersulfone from divinyl sulfone and water. | Ratzenböck, K., et al. 2022. Chem Sci. 13: 6920-6928. PMID: 35774179
- Controlling Gas Generation of Li-Ion Battery through Divinyl Sulfone Electrolyte Additive. | Choi, WI., et al. 2022. Int J Mol Sci. 23: PMID: 35806333
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Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Divinyl sulfone, 10 g | sc-255120 | 10 g | $117.00 | |||
Divinyl sulfone, 50 g | sc-255120A | 50 g | $266.00 |