Molecular structure of Dithiobutylamine Hydrochloride, CAS Number: 1363376-98-0
Dithiobutylamine Hydrochloride (CAS 1363376-98-0)
Alternate Names:
(2S)-2-Amino-1,4-dimercaptobutane hydrochloride
CAS Number:
1363376-98-0
Molecular Weight:
173.73
Molecular Formula:
C4H11NS2•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Dithiobutylamine Hydrochloride is a water-soluble compound known for its strong disulfide-reducing properties. It capabable of reducing the enzyme papainn which has a relatively anionic active site. It serves as an effective alternative to DTT, offering faster and more potent reduction at lower pH levels. This non-volatile and almost odorless solid can be synthesized from L-aspartic acid.
Dithiobutylamine Hydrochloride (CAS 1363376-98-0) References
- A potent, versatile disulfide-reducing agent from aspartic acid. | Lukesh, JC., et al. 2012. J Am Chem Soc. 134: 4057-9. PMID: 22353145
- Thiols and selenols as electron-relay catalysts for disulfide-bond reduction. | Lukesh, JC., et al. 2013. Angew Chem Int Ed Engl. 52: 12901-4. PMID: 24123634
- Biophysical and proteomic characterization strategies for cysteine modifications in Ras GTPases. | Hobbs, GA., et al. 2014. Methods Mol Biol. 1120: 75-96. PMID: 24470020
- Phosphines are ribonucleotide reductase reductants that act via C-terminal cysteines similar to thioredoxins and glutaredoxins. | Domkin, V. and Chabes, A. 2014. Sci Rep. 4: 5539. PMID: 24986213
- Pyrazine-derived disulfide-reducing agent for chemical biology. | Lukesh, JC., et al. 2014. Chem Commun (Camb). 50: 9591-4. PMID: 25014913
- Coordination properties of dithiobutylamine (DTBA), a newly introduced protein disulfide reducing agent. | Adamczyk, J., et al. 2015. Inorg Chem. 54: 596-606. PMID: 25531180
- Conformational stability and catalytic activity of PTEN variants linked to cancers and autism spectrum disorders. | Johnston, SB. and Raines, RT. 2015. Biochemistry. 54: 1576-82. PMID: 25647146
- Implications of macromolecular crowding and reducing conditions for in vitro ribosome construction. | Fritz, BR., et al. 2015. Nucleic Acids Res. 43: 4774-84. PMID: 25897121
- Small molecule diselenide additives for in vitro oxidative protein folding. | Reddy, PS. and Metanis, N. 2016. Chem Commun (Camb). 52: 3336-9. PMID: 26822519
- The biological inorganic chemistry of zinc ions. | Krężel, A. and Maret, W. 2016. Arch Biochem Biophys. 611: 3-19. PMID: 27117234
- Pretreatment of bovine sperm with dithiobutylamine (DTBA) significantly improves embryo development after ICSI. | Suttirojpattana, T., et al. 2016. J Reprod Dev. 62: 577-585. PMID: 27523189
- High efficiency reduction capability for the formation of Fab׳ antibody fragments from F(ab)2 units. | Crivianu-Gaita, V., et al. 2015. Biochem Biophys Rep. 2: 23-28. PMID: 29124142
- Bovine ICSI: limiting factors, strategies to improve its efficiency and alternative approaches. | Fuentes, F., et al. 2022. Zygote. 30: 749-767. PMID: 36082429
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Dithiobutylamine Hydrochloride, 1 g | sc-497280 | 1 g | $255.00 |