Disuccinimidyl glutarate CAS: 79642-50-5
MF: C13H14N2O8
MW: 326.26

Disuccinimidyl glutarate (CAS 79642-50-5)

Disuccinimidyl glutarate | CAS 79642-50-5 is rated 5.0 out of 5 by 1.
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Alternate Names: Disuccinimidyl glutarate is also known as DSG and Di(N-succinimidyl) glutarate.
Application: Disuccinimidyl glutarate is an amine-reactive, NHS ester-based crosslinker useful in isolation of the insulin receptor.
CAS Number: 79642-50-5
Purity: ≥97%
Molecular Weight: 326.26
Molecular Formula: C13H14N2O8
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

Disuccinimidyl glutarate is a membrane-soluble, amine-reactive NHS ester-based homobifunctional crosslinker. Disuccinimidyl glutarate crosslinking takes place through amine-reactive NHS esters at both ends of a 5-atom (7.7 angstrom) spacer arm. Disuccinimidyl glutarate has been employed in the isolation of the insulin receptor.


References

1. Lee, C., Guo, J., Zeng, W., Kim, S., She, J., Cang, C., ... & Jiang, Y. (2017). The lysosomal potassium channel TMEM175 adopts a novel tetrameric architecture. Nature, 547(7664), 472.
2. Madsen, J. G. S., Rauch, A., Van Hauwaert, E. L., Schmidt, S. F., Winnefeld, M., & Mandrup, S. (2017). Integrated analysis of motif activity and gene expression changes of transcription factors. Genome Research, gr-227231.
3. Zhang, Y. J., Caulfield, T., Xu, Y. F., Gendron, T. F., Hubbard, J., Stetler, C., ... & Petrucelli, L. (2013). The dual functions of the extreme N-terminus of TDP-43 in regulating its biological activity and inclusion formation. Human molecular genetics.

Physical State :
Solid
Solubility :
Soluble in water (partly miscible), DMSO, and DMF.
Storage :
Store at -20° C
Melting Point :
142-145° C
Boiling Point :
~485.1° C at 760 mmHg (Predicted)
Density :
~1.53 g/cm3 (Predicted)
Refractive Index :
n20D ~1.57 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
4432628
MDL Number :
MFCD00153597
Beilstein Registry :
8575145
SMILES :
C1CC(=O)N(C1=O)OC(=O)CCCC(=O)ON2C(=O)CCC2=O

Download SDS (MSDS)

Certificate of Analysis

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Disuccinimidyl glutarate (CAS 79642-50-5)  Product Citations

See how others have used Disuccinimidyl glutarate (CAS 79642-50-5). Click on the entry to view the PubMed entry .

Citations 1 to 7 of 7 total

PMID: # 31422874  2019. Mol. Cell.

PMID: # 29259012  Kang, J.|Shin, SH.|Yoon, H.|Huh, J.|Shin, HW.|Chun, YS.|Park, JW.| et al. 2018. Cancer Res. 78: 1184-1199.

PMID: # 29899353  Papachristou, EK. et al. 2018. Nat Commun. 9: 2311.

PMID: # 27056598  Battisti, V. et al. 2016. J. Mol. Biol. 428: 2329-43.

PMID: # 26691724  Buffet, C. et al. 2015. PloS one. 10: e0145484.

PMID: # 25922909  Giri, S. et al. 2015. Elife. 4:

PMID: # 31622280  JCI Insight.

Citations 1 to 7 of 7 total
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Rated 5 out of 5 by from Aoki et al Aoki et al. (PubMed ID 241356989) used Disuccinimidyl glutarate (DSG) as a bi-functional cross-linking agent, along with DSP, in Drosophila embryos. -SCBT Publication Review
Date published: 2015-05-26
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