Disodium clodronate tetrahydrate (CAS 88416-50-6)
QUICK LINKS
Disodium clodronate tetrahydratebelongs to the class of bisphosphonates. Disodium clodronate tetrahydrate acts by inhibiting the activity of a group of enzymes called osteoclasts. Osteoclasts are responsible for breaking down bone tissue. Disodium clodronate tetrahydrate may find applications in the study of bone mimicry materials. Researchers working on synthetic bone grafts or scaffolds for tissue engineering can explore the use of bisphosphonates to replicate the natural bone environment better and promote cell adhesion and growth. In the field of material science, the properties of disodium clodronate tetrahydrate can be exploited in the synthesis and modification of materials. For example, its ability to bind to calcium makes it an interesting candidate for the development of coatings or treatments for materials that interact with biological systems.
Disodium clodronate tetrahydrate (CAS 88416-50-6) References
- Treatment effects of bisphosphonates on ovariectomy-induced osteopenia in rats: comparison between clodronate and etidronate. | Itoh, F., et al. 1999. J Bone Miner Metab. 17: 252-8. PMID: 10575589
- Clodronate in the prevention and treatment of skeletal metastasis. | Gulley, J. and Dahut, WL. 2005. Expert Rev Anticancer Ther. 5: 221-30. PMID: 15877520
- Development and application of a high-performance liquid chromatography-mass spectrometry method to determine alendronate in human urine. | Tarcomnicu, I., et al. 2007. J Chromatogr A. 1160: 21-33. PMID: 17602696
- Hypercalcaemic crisis due to primary hyperparathyroidism - a systematic literature review and case report. | Gurrado, A., et al. 2012. Endokrynol Pol. 63: 494-502. PMID: 23339009
- Blood concentrations of small extracellular vesicles are determined by a balance between abundant secretion and rapid clearance. | Matsumoto, A., et al. 2020. J Extracell Vesicles. 9: 1696517. PMID: 31807238
- Pro-inflammatory macrophages coupled with glycolysis remodel adipose vasculature by producing platelet-derived growth factor-B in obesity. | Onogi, Y., et al. 2020. Sci Rep. 10: 670. PMID: 31959796
- Hepatosplenic phagocytic cells indirectly contribute to anti-PEG IgM production in the accelerated blood clearance (ABC) phenomenon against PEGylated liposomes: Appearance of an unexplained mechanism in the ABC phenomenon. | El Sayed, MM., et al. 2020. J Control Release. 323: 102-109. PMID: 32278827
- Adjuvant Antitumor Immunity Contributes to the Overall Antitumor Effect of Pegylated Liposomal Doxorubicin (Doxil®) in C26 Tumor-Bearing Immunocompetent Mice. | Takayama, T., et al. 2020. Pharmaceutics. 12: PMID: 33086690
- Incorporating Gangliosides into PEGylated Cationic Liposomes that Complexed DNA Attenuates Anti-PEG Antibody Production but Not Anti-DNA Antibody Production in Mice. | Qelliny, MR., et al. 2021. Mol Pharm. 18: 2406-2415. PMID: 33896187
- A 31P CP/MAS NMR study on dehydration of disodium clodronate tetrahydrate. | Timonen, JT., et al. 1998. Pharm Res. 15: 110-5. PMID: 9487556
- Periarticular bone alterations in chronic antigen-induced arthritis: free and liposome-encapsulated clodronate prevent loss of bone mass in the secondary spongiosa. | Oelzner, P., et al. 1999. Clin Immunol. 90: 79-88. PMID: 9884355
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Disodium clodronate tetrahydrate, 100 mg | sc-497247 | 100 mg | $344.00 |