DIS3L2 Antibody (6C7B2): sc-517218
- DIS3L2 Antibody (6C7B2) is a mouse monoclonal IgG1 DIS3L2 antibody provided at 50 µg/50 ml
- raised against a recombinant protein corresponding to amino acids 27-250 of DIS3L2 of human origin
- recommended for detection of DIS3L2 of human origin by WB, IP, IF, IHC(P), FCM and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for DIS3L2 Antibody (6C7B2). This work is in progress.
QUICK LINKS
DIS3L2 Antibody (6C7B2) is a mouse monoclonal IgG1 antibody that detects DIS3L2 protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), flow cytometry (FCM), and enzyme-linked immunosorbent assay (ELISA). DIS3L2 (6C7B2) antibody is available as a non-conjugated anti-DIS3L2 monoclonal isotype antibody. DIS3L2 protein, consisting of 885 amino acids, plays a crucial role as an exonuclease within the exosome complex, which is essential for degrading unstable mRNAs containing AU-rich elements in untranslated 3′ regions. This process maintains cellular homeostasis and regulates gene expression by ensuring faulty or unnecessary mRNAs are efficiently removed from cells. Defects or chromosomal translocations involving DIS3L2 gene have been linked to Marfanoid habitus, a genetic disorder manifesting in skeletal, ocular, and cardiovascular abnormalities. DIS3L2 is expressed in five isoforms due to alternative splicing, highlighting regulatory potential in various cellular contexts.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
DIS3L2 Antibody (6C7B2) References:
- The mammalian exosome mediates the efficient degradation of mRNAs that contain AU-rich elements. | Mukherjee, D., et al. 2002. EMBO J. 21: 165-74. PMID: 11782436
- Autoantibodies directed to novel components of the PM/Scl complex, the human exosome. | Brouwer, R., et al. 2002. Arthritis Res. 4: 134-8. PMID: 11879549
- Protein-protein interactions between human exosome components support the assembly of RNase PH-type subunits into a six-membered PNPase-like ring. | Raijmakers, R., et al. 2002. J Mol Biol. 323: 653-63. PMID: 12419256
- The association of the human PM/Scl-75 autoantigen with the exosome is dependent on a newly identified N terminus. | Raijmakers, R., et al. 2003. J Biol Chem. 278: 30698-704. PMID: 12788944
- Caspase-mediated cleavage of the exosome subunit PM/Scl-75 during apoptosis. | Schilders, G., et al. 2007. Arthritis Res Ther. 9: R12. PMID: 17280603
- Overexpression of the C-type natriuretic peptide (CNP) is associated with overgrowth and bone anomalies in an individual with balanced t(2;7) translocation. | Bocciardi, R., et al. 2007. Hum Mutat. 28: 724-31. PMID: 17373680
- Human cell growth requires a functional cytoplasmic exosome, which is involved in various mRNA decay pathways. | van Dijk, EL., et al. 2007. RNA. 13: 1027-35. PMID: 17545563
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
DIS3L2 Antibody (6C7B2) | sc-517218 | 50 µg/50 ml | $322.00 |