Molecular structure of Diquafosol Sodium Salt
Diquafosol Sodium Salt (CAS CAS 59985-21-6)
Alternate Names:
Uridine 5′-(Pentahydrogen Tetraphosphate), P′′′→5′-Ester with Uridine Sodium Salt; P1,P4-Diuridine 5′- Tetraphosphate Sodium Salt
Application:
Diquafosol Sodium Salt is a dinucleoside derivative of uridine that acts as a selective P2Y2 receptor agonist.
CAS Number:
CAS 59985-21-6
Purity:
≥90%
Molecular Weight:
790.31 (free acid)
Molecular Formula:
C18H26N4O23P4•(xNa)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Diquafosol Sodium Salt is a dinucleoside derivative of uridine that acts as a selective P2Y2 receptor agonist.
Diquafosol Sodium Salt (CAS CAS 59985-21-6) References
- Effects of diquafosol sodium eye drops on tear film stability in short BUT type of dry eye. | Shimazaki-Den, S., et al. 2013. Cornea. 32: 1120-5. PMID: 23635860
- Facilitation of tear fluid secretion by 3% diquafosol ophthalmic solution in normal human eyes. | Yokoi, N., et al. 2014. Am J Ophthalmol. 157: 85-92.e1. PMID: 24200231
- The effects of 3% diquafosol sodium application on the tear functions and ocular surface of the Cu,Zn-superoxide dismutase-1 (Sod1)-knockout mice. | Kojima, T., et al. 2014. Mol Vis. 20: 929-38. PMID: 24991185
- Analysis of Meibum Before and After Intraductal Meibomian Gland Probing in Eyes With Obstructive Meibomian Gland Dysfunction. | Nakayama, N., et al. 2015. Cornea. 34: 1206-8. PMID: 26226474
- The increase of aqueous tear volume by diquafosol sodium in dry-eye patients with Sjögren's syndrome: a pilot study. | Yokoi, N., et al. 2016. Eye (Lond). 30: 857-64. PMID: 27055679
- Diquafosol Ophthalmic Solution Increases Pre- and Postlens Tear Film During Contact Lens Wear in Rabbit Eyes. | Nagahara, Y., et al. 2017. Eye Contact Lens. 43: 378-382. PMID: 27243352
- Comparison of the efficacy between topical diquafosol and artificial tears in the treatment of dry eye following cataract surgery: A meta-analysis of randomized controlled trials. | Zhao, X., et al. 2017. Medicine (Baltimore). 96: e8174. PMID: 28953672
- Effect of topical 3% diquafosol sodium on eyes with dry eye disease and meibomian gland dysfunction. | Amano, S. and Inoue, K. 2017. Clin Ophthalmol. 11: 1677-1682. PMID: 29075094
- The effects of 3% diquafosol sodium eye drop application on meibomian gland and ocular surface alterations in the Cu, Zn-superoxide dismutase-1 (Sod1) knockout mice. | Ikeda, K., et al. 2018. Graefes Arch Clin Exp Ophthalmol. 256: 739-750. PMID: 29484560
- Diquafosol Sodium Inhibits Apoptosis and Inflammation of Corneal Epithelial Cells Via Activation of Erk1/2 and RSK: In Vitro and In Vivo Dry Eye Model. | Park, JH., et al. 2018. Invest Ophthalmol Vis Sci. 59: 5108-5115. PMID: 30372737
- Efficacy of Topical Cyclosporine Nanoemulsion 0.05% Compared with Topical Cyclosporine Emulsion 0.05% and Diquafosol 3% in Dry Eye. | Park, CH., et al. 2019. Korean J Ophthalmol. 33: 343-352. PMID: 31389210
- The Effects of 3% Diquafosol Sodium Eye Drops on Tear Function and the Ocular Surface of Cu, Zn-Superoxide Dismutase-1 (Sod1) Knockout Mice Treated with Antiglaucoma Eye Medications. | Yagi-Yaguchi, Y., et al. 2020. Diagnostics (Basel). 10: PMID: 31906291
- Effects of eye drops containing a mixture of 3% diquafosol sodium and tocopherol acetate (vitamin E) on the ocular surface of murine dry eye. | Li, L., et al. 2021. Cutan Ocul Toxicol. 40: 350-358. PMID: 34496685
- Diquafosol sodium reduces neuronal activity in trigeminal subnucleus caudalis in a rat model of chronic dry eye disease. | Katagiri, A., et al. 2023. Neurosci Lett. 792: 136939. PMID: 36341926
- Analysis of risk factors for dry eye disease and effect of diquafosol sodium ophthalmic solution on the tear film after vitrectomy in patients with type 2 diabetes mellitus: a preliminary study. | Du, X., et al. 2022. Int Ophthalmol.. PMID: 36436170
Activator of:
P2Y2.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Diquafosol Sodium Salt, 5 mg | sc-497244 | 5 mg | $390.00 | |||
Diquafosol Sodium Salt, 50 mg | sc-497244A | 50 mg | $2800.00 |