Molecular structure of Dipyridamole, CAS Number: 58-32-2
Dipyridamole (CAS 58-32-2)
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Alternate Names:
Persantin; Curanty; 2,6-Bis(diethanolamine)-4,8-dipiperidinopyrimido[5,4-d]pyrimidine
Application:
Dipyridamole is a phosphodiester, cGMP, and non-specific nucleoside transport inhibitor
CAS Number:
58-32-2
Purity:
≥98%
Molecular Weight:
504.63
Molecular Formula:
C24H40N8O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Dipyridamole is a PDE (phosphodiesterase) inhibitor with antioxidant properties. This compound may act to suppress high glucose-induced osteopontin mRNA expression and protein secretion, as well as inhibit cAMP and cGMP hydrolysis. Research indicates that Dipyridamole is a non-specific nucleoside transport inhibitor with the ability to increase the effects of adenosine in sinoatrial and atrioventricular nodes. Dipyridamole is an inhibitor of ENT1 and ENT2.
Dipyridamole (CAS 58-32-2) References
- Cloning and characterization of a novel human phosphodiesterase that hydrolyzes both cAMP and cGMP (PDE10A). | Fujishige, K., et al. 1999. J Biol Chem. 274: 18438-45. PMID: 10373451
- Cyclic nucleotide phosphodiesterase (PDE) superfamily: a new target for the development of specific therapeutic agents. | Lugnier, C. 2006. Pharmacol Ther. 109: 366-98. PMID: 16102838
- Dipyridamole suppresses high glucose-induced osteopontin secretion and mRNA expression in rat aortic smooth muscle cells. | Hsieh, MS., et al. 2010. Circ J. 74: 1242-50. PMID: 20453393
- Dipyridamole analogs as pharmacological inhibitors of equilibrative nucleoside transporters. Identification of novel potent and selective inhibitors of the adenosine transporter function of human equilibrative nucleoside transporter 4 (hENT4). | Wang, C., et al. 2013. Biochem Pharmacol. 86: 1531-40. PMID: 24021350
- Changes of electrocardiogram and hemodynamics in response to dipyridamole: In vivo comparative analyses using anesthetized beagle dogs and microminipigs. | Ando, K., et al. 2018. J Pharmacol Sci. 136: 86-92. PMID: 29398450
- Multiple molecular forms of cyclic nucleotide phosphodiesterase in cardiac and smooth muscle and in platelets. Isolation, characterization, and effects of various reference phosphodiesterase inhibitors and cardiotonic agents. | Weishaar, RE., et al. 1986. Biochem Pharmacol. 35: 787-800. PMID: 3006691
- Bone Tissue Engineering in the Growing Calvaria Using Dipyridamole-Coated, Three-Dimensionally-Printed Bioceramic Scaffolds: Construct Optimization and Effects on Cranial Suture Patency. | Maliha, SG., et al. 2020. Plast Reconstr Surg. 145: 337e-347e. PMID: 31985634
- Lack of interferon production by dipyridamole. | Havlin, KA., et al. 1988. J Interferon Res. 8: 135-6. PMID: 3379323
- The effect of the nucleoside transport inhibitor dipyridamole on the incorporation of [3H]thymidine in the rat. | Newell, DR., et al. 1986. Biochem Pharmacol. 35: 3871-7. PMID: 3778511
- Effect of dipyridamole on prostaglandin-induced ocular hypertension in rabbits. | Podos, SM. 1979. Invest Ophthalmol Vis Sci. 18: 646-8. PMID: 447464
- Inhibitory mechanism of dipyridamole on platelet aggregation ex vivo. | Fukawa, K., et al. 1982. Thromb Res. 27: 333-40. PMID: 6291192
- Cloning and characterization of a cAMP-specific cyclic nucleotide phosphodiesterase. | Soderling, SH., et al. 1998. Proc Natl Acad Sci U S A. 95: 8991-6. PMID: 9671792
- Pharmacological analysis of the activity of the adenosine uptake inhibitor, dipyridamole, on the sinoatrial and atrioventricular nodes of the guinea-pig. | Meester, BJ., et al. 1998. Br J Pharmacol. 124: 729-41. PMID: 9690865
Inhibitor of:
β thromboglobulin, 2410131K14Rik, ABCG1, ACSS1, ADF, ADK, AMPD2, AP4A Hydrolase, band 3, BPNT1, C22orf13, CAT-4, CD42a, CD42b, CD42c, CD73, CTL3, ENT1, ENT2, ERMAP, Ferroportin-1, GPVI, IRP-1, MATE1, MFSD9, MRP1, NT5DC1, Olfr1031, Olfr1065, Olfr107, Olr1432, Olr1514, Olr1646, Olr483, OTTMUSG00000019145, Pannexin-2, PDE, PDE6Aα, PDE6D, PDE6G, PDE6H, PDE7B, PDE8B, PECAM-1, PED7A, PF-4, PKA IIβ reg, RAPGEFL1, RD3L, SAHH, sGC α2, sGC β1, SLC29 (solute carrier family 29), SNX12, SVCT3, Thrombospondin 1, TREML1, VPAC2, and VWF.Activator of:
1110008L16Rik, 2′-PDE, 5′-nucleotidas, 5′-nucleotidase, ABCC12, ACD, Adad2, Adenosine A2A-R, AK1, AKAP 3, APRT, Atase, ATP6E, Basonuclin 2, BC031181, c-GMP, C20orf152, C5orf23, CA XIV, calicin, cAMP-GEFII, CD39L2, CD39L4, CDD, cGKII, Chromozym PK, Chromozym t-PA, CINAP, CNBD2, CNG-1, CNG-2, CNG-3, CNT3, CREST, DOHH, EG434727, ENT2, GCAP2, Glycophorin D, GPR179, GUCD1, Gucy2g, HSPC144, IVNS1ABP, LAGE-3, LMBRD2, LZTFL1, MaxiKα, MBNL2, MOBKL2A, MRP-L16, MSG1, MYH15, NUDT19, NUDT3, P2RY8, P2X5, P2Y11, P4H-TM, PCYOX1L, PDE10A, PDE11A, PDE1B, PDE2A, PDE5A, PDE6α, PDE6β, PDE8A, PDE9A, PHKG2, PKA IIα reg, PKAγ, PNP, PP2A-B55-α, PP2A-B56-γ, Ppp1r3d, PPP1R3E, PPP1R3G, PRPSL1, PRTFDC1, Punc, rcRPE, Rpp25, RPS4YX, sGC β1, SLC17A9, SPDYE2L, t-GMP, TAFI, TAPBPL, TEM7R, TMEM118, TNNI3K, UPase, and VWA5A.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Dipyridamole, 1 g | sc-200717 | 1 g | $30.00 | |||
Dipyridamole, 5 g | sc-200717A | 5 g | $100.00 |