Diprotin B (CAS 90614-49-6)
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Diprotin B is a dipeptidyl peptidase IV (DPP-IV) inhibitor that functions by blocking the activity of the DPP-IV enzyme. This inhibition prevents the degradation of incretin hormones such as glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP). By blocking DPP-IV, Diprotin B increases the levels of these incretin hormones, which in turn enhances insulin secretion and suppresses glucagon release. This mechanism of action ultimately leads to improved glucose homeostasis and regulation of blood sugar levels. At the molecular level, Diprotin B binds to the active site of DPP-IV, preventing the enzyme from cleaving the incretin hormones and allowing them to exert their physiological effects. Diprotin B′s function in experiment involves the study of glucose metabolism and the regulation of insulin secretion, providing insights into the role of DPP-IV in these processes.
Diprotin B (CAS 90614-49-6) References
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- Are diprotin A (Ile-Pro-Ile) and diprotin B (Val-Pro-Leu) inhibitors or substrates of dipeptidyl peptidase IV? | Rahfeld, J., et al. 1991. Biochim Biophys Acta. 1076: 314-6. PMID: 1671823
- Crystal structures of human dipeptidyl peptidase IV in its apo and diprotin B-complexed forms. | Hiramatsu, H., et al. 2007. Acta Biochim Biophys Sin (Shanghai). 39: 335-43. PMID: 17492130
- Dipeptidyl peptidase IV (DP IV) and superoxide dismutase activity in thymus-derived lymphocytes: effects of inhibitory peptides and Zn2+ in vitro. | Endröczi, E., et al. 1990. Acta Physiol Hung. 75: 35-44. PMID: 1971138
- Diprotins A and B, inhibitors of dipeptidyl aminopeptidase IV, produced by bacteria. | Umezawa, H., et al. 1984. J Antibiot (Tokyo). 37: 422-5. PMID: 6427168
- Detection of dipeptidyl peptidase IV in glioma C6 and neuroblastoma SK-N-SH cell lines. | Sedo, A. and Revoltella, RP. 1995. Biochem Cell Biol. 73: 113-5. PMID: 7662310
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Diprotin B, 5 mg | sc-294372 | 5 mg | $23.00 | |||
Diprotin B, 25 mg | sc-294372A | 25 mg | $50.00 |