DIPPMPO is, beside DEPMPO (sc-202132), the most efficient spin trap for the in vitro detection of O-, N-, S-, and C-centered free radicals. DIPPMPO is more lipophilic (Kp=2.1) than DEPMPO (sc-202132) with a longer life-time than DMPO (sc-202587).
1. Chalier, Florence, et al., 2002. 5-Diisopropoxyphosphoryl-5-methyl-1-pyrroline N-oxide, DIPPMPO, a crystalline analog of the nitrone DEPMPO: synthesis and spin trapping properties. Journal of the Chemical Society, Perkin Transactions 2. 2002(12):2110-2117.
2. Culcasi, Marcel., et al., 2006. The line asymmetry of electron spin resonance spectra as a tool to determine the cis:trans ratio for spin-trapping adducts of chiral pyrrolines N-oxides: the mechanism of formation of hydroxyl radical adducts of EMPO, DEPMPO, and DIPPMPO in the ischemic-reperfused rat liver. Free radical biology & medicine. 40(9): 1524-38. PMID: 16632113
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