Date published: 2025-10-18

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Diphenylmethane (CAS 101-81-5)

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Alternate Names:
Benzylphenyl
CAS Number:
101-81-5
Purity:
≥99%
Molecular Weight:
168.23
Molecular Formula:
C13H12
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Diphenylmethane functions as a reactant in organic synthesis, particularly in the production of dyes and perfumes. It acts as a precursor in the formation of various organic compounds, participating in reactions such as Friedel-Crafts alkylation and acylation. Diphenylmethane′s mechanism of action involves its ability to undergo substitution reactions with other reagents, leading to the formation of new carbon-carbon or carbon-heteroatom bonds. Diphenylmethane can also serve as a building block for the synthesis of complex organic molecules, contributing to the diversification of chemical structures. Its role in these reactions allows for the creation of novel compounds with potential applications in various fields of study.


Diphenylmethane (CAS 101-81-5) References

  1. Sonochemical polymerization of diphenylmethane.  |  Nikitenko, SI., et al. 2003. Ultrason Sonochem. 10: 11-5. PMID: 12457945
  2. Diphenylmethane skeleton as a multi-template for nuclear receptor ligands: preparation of FXR and PPAR ligands.  |  Kainuma, M., et al. 2006. Bioorg Med Chem Lett. 16: 3213-8. PMID: 16617018
  3. Diphenylmethane-mediated transmethylation of methylbenzenes over H-zeolites.  |  Svelle, S., et al. 2006. J Am Chem Soc. 128: 5618-9. PMID: 16637612
  4. One new diphenylmethane glycoside from the leaves of Psidium guajava L.  |  Shu, JC., et al. 2012. Nat Prod Res. 26: 1971-5. PMID: 22085357
  5. New diphenylmethane derivatives as peroxisome proliferator-activated receptor alpha/gamma dual agonists endowed with anti-proliferative effects and mitochondrial activity.  |  Piemontese, L., et al. 2017. Eur J Med Chem. 127: 379-397. PMID: 28076827
  6. Assessment of dermal uptake of diphenylmethane-4,4'-diisocyanate using tape stripping and biological monitoring.  |  Hamada, H., et al. 2018. Eur J Dermatol. 28: 143-148. PMID: 29620002
  7. [Determination of diphenylmethane diisocyanate in workplace air by HPLC with impregnated filter membrane].  |  Wang, X., et al. 2019. Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 37: 389-392. PMID: 31177723
  8. Animal models of cathartic colon.  |  Meng, YY., et al. 2021. World J Clin Cases. 9: 1251-1258. PMID: 33644192
  9. Identified Seaweed Compound Diphenylmethane Serves as an Efflux Pump Inhibitor in Drug-Resistant Escherichia coli.  |  Lu, WJ., et al. 2021. Antibiotics (Basel). 10: PMID: 34827316
  10. Molecular Modelling Study and Antibacterial Evaluation of Diphenylmethane Derivatives as Potential FabI Inhibitors.  |  Hasan, S., et al. 2023. Molecules. 28: PMID: 37049763
  11. RIFM fragrance ingredient safety assessment, diphenylmethane, CAS Registry Number 101-81-5.  |  Api, AM., et al. 2023. Food Chem Toxicol. 176 Suppl 1: 113797. PMID: 37116775
  12. [Allergy to diphenylmethane diisocyanate: apropos of a case].  |  Bonneau, JC. 1994. Allerg Immunol (Paris). 26: 383-5. PMID: 7702731
  13. Death due to asthma at workplace in a diphenylmethane diisocyanate-sensitized subject.  |  Carino, M., et al. 1997. Respiration. 64: 111-3. PMID: 9044486

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Diphenylmethane, 25 g

sc-234786
25 g
$26.00