Molecular structure of Diphenhydramine N-Oxide, CAS Number: 3922-74-5
Diphenhydramine N-Oxide (CAS 3922-74-5)
Alternate Names:
2-(Diphenylmethoxy)-N,N-dimethylethanamine N-Oxide; (Dimethylamino)ethyl Benzhydryl Ether N-Oxide; NSC 9091
CAS Number:
3922-74-5
Molecular Weight:
271.35
Molecular Formula:
C17H21NO2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Diphenhydramine N-Oxide is a compound that functions as a metabolite of diphenhydramine, an antihistamine. In a research and development setting, it acts as a substrate for cytochrome P450 enzymes, specifically CYP2D6, which is involved in the metabolism of various xenobiotics. At the molecular level, diphenhydramine N-Oxide is involved in the oxidation-reduction reactions mediated by cytochrome P450 enzymes, contributing to the biotransformation of diphenhydramine and potentially other substrates.
Diphenhydramine N-Oxide (CAS 3922-74-5) References
- Metabolism of the ethanolamine-type antihistamine diphenhydramine (Benadryl) by the fungus Cunninghamella elegans. | Moody, JD., et al. 2000. Appl Microbiol Biotechnol. 53: 310-5. PMID: 10772471
- Pharmacokinetics and renal excretion of diphenhydramine and its metabolites, diphenylmethoxyacetic acid and diphenhydramine-N-oxide, in developing lambs. | Wong, H., et al. 2000. J Pharm Sci. 89: 1362-70. PMID: 10980511
- Identification of diphenhydramine metabolites in human urine by capillary electrophoresis-ion trap-mass spectrometry. | Baldacci, A., et al. 2004. Electrophoresis. 25: 1607-14. PMID: 15188248
- The antihistamine diphenhydramine is extremely persistent in agricultural soil. | Topp, E., et al. 2012. Sci Total Environ. 439: 136-40. PMID: 23063919
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Diphenhydramine N-Oxide, 5 mg | sc-497035A | 5 mg | $108.00 | |||
Diphenhydramine N-Oxide, 50 mg | sc-497035 | 50 mg | $360.00 |