Molecular structure of Diphacinone, CAS Number: 82-66-6
Diphacinone (CAS 82-66-6)
Alternate Names:
diphenadione; 2-diphenylacetylindan-1,3-dione
Application:
Diphacinone is an anticoagulant rodenticide used to control infestations
CAS Number:
82-66-6
Molecular Weight:
340.37
Molecular Formula:
C23H16O3
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Diphacinone is an anticoagulant rodenticide widely used to control rodent infestations. Rodenticide anticoagulants inhibit the dithiothreitol-dependent vitamin K reductase reactions and prevent vitamin K hydroquinone regeneration, which is evident by the significant increase in serum vitamin 2,3 epoxide levels and a concurrent increase in the serum vitamin K epoxide-vitamin K ratio. Inhibition of vitamin K reductases indirectly inhibits active prothrombin complex protein formation. Rodenticide anticoagulants inhibit vitamin K regeneration almost immediately, but the anticoagulant effect is delayed until the vitamin K stores are depleted and sufficient active coagulation factors are removed from circulation.
Diphacinone (CAS 82-66-6) References
- Diphenadione residues in milk of cattle. | Bullard, RW., et al. 1976. J Agric Food Chem. 25: 79-81. PMID: 1036746
- Determination of chlorophacinone and diphenadione residues in biological materials. | Bullard, RW., et al. 1975. J Agric Food Chem. 23: 72-4. PMID: 1173369
- DIPHENADIONE AS AN ANTICOAGULANT IN ACUTE MYOCARDIAL INFARCTION. | VALERO, A. 1964. Isr Med J. 23: 111-5. PMID: 14197002
- Confirmation of indandione rodenticide toxicoses by mass spectrometry/mass spectrometry. | Braselton, WE., et al. 1992. J Vet Diagn Invest. 4: 441-6. PMID: 1457548
- Determination of the rodenticides warfarin, diphenadione and chlorophacinone in soil samples by HPLC-DAD. | Medvedovici, A., et al. 1997. Talanta. 44: 1633-40. PMID: 18966902
- Anticoagulant rodenticide screening in dogs: 123 cases (1996-2003). | Waddell, LS., et al. 2013. J Am Vet Med Assoc. 242: 516-21. PMID: 23363284
- Toxicokinetics and coagulopathy threshold of the rodenticide diphacinone in eastern screech-owls (Megascops asio). | Rattner, BA., et al. 2014. Environ Toxicol Chem. 33: 74-81. PMID: 24014246
- Effectiveness of rodenticides for managing invasive roof rats and native deer mice in orchards. | Baldwin, RA., et al. 2014. Environ Sci Pollut Res Int. 21: 5795-802. PMID: 24443051
- Nontarget mortality of New Zealand lesser short-tailed bats (Mystacina tuberculata) caused by diphacinone. | Dennis, GC. and Gartrell, BD. 2015. J Wildl Dis. 51: 177-86. PMID: 25375946
- Cluster of cases of massive hemorrhage associated with anticoagulant detection in race horses. | Carvallo, FR., et al. 2015. J Vet Diagn Invest. 27: 112-6. PMID: 25525145
- Ultrasensitive determination of diphacinone by flow injection chemiluminescence: application to quantification in biofluids and photodegradation monitoring in water samples. | Tan, X., et al. 2014. J AOAC Int. 97: 1725-9. PMID: 25632450
- Diagnostic importance of vitamin K1 and its epoxide measured in serum of dogs exposed to an anticoagulant rodenticide. | Mount, ME. and Kass, PH. 1989. Am J Vet Res. 50: 1704-9. PMID: 2802299
- Potential impact of diphacinone application strategies on secondary exposure risk in a common rodent pest: implications for management of California ground squirrels. | Baldwin, RA., et al. 2021. Environ Sci Pollut Res Int. 28: 45891-45902. PMID: 33881695
- Toxicokinetic analysis of the anticoagulant rodenticides warfarin & diphacinone in Egyptian fruit bats (Rousettus aegyptiacus) as a comparative sensitivity assessment for Bonin fruit bats (Pteropus pselaphon). | Takeda, K., et al. 2022. Ecotoxicol Environ Saf. 243: 113971. PMID: 35981482
- Vampire bat control by systemic treatment of livestock with an anticoagulant. | Thompson, RD., et al. 1972. Science. 177: 806-8. PMID: 5068491
Inhibitor of:
GGCX.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Diphacinone, 100 mg | sc-257374 | 100 mg | $240.00 |