Molecular structure of Dipeptidylpeptidase IV Inhibitor IV, K579, CAS Number: 440100-64-1
Dipeptidylpeptidase IV Inhibitor IV, K579 (CAS 440100-64-1)
See product citations (3)
Alternate Names:
(S)-1-(4-Methyl-1-(2-pyrimidinyl)-4-piperidylamino)acetyl-2-pyrrolidinecarbonitrile
Application:
Dipeptidylpeptidase IV Inhibitor IV, K579 is an agent that acts as a low-binding CD26 inhibitor
CAS Number:
440100-64-1
Purity:
≥97%
Molecular Weight:
328.41
Molecular Formula:
C17H24N6O
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
K579 is a an agent that acts as a low-binding dipeptidyl peptidase IV (DPP IV) inhibitor. The inhibitor is a cyanopyrrolidine compound that is more potent and acts as a slower binding inhibitor than the used dipeptidyl peptidase IV inhibitor, NVP-DPP728. Research shows that it can conserve endogenously secreted active forms of glucagon-lke peptide-1, heighten insulin response and can ameliorate glucose excursion during oral glucose tolerance tests in rats. K579 has also been shown to reduce plasm glucose concentration, as well as suppress blood glucose elevation in rats.
Dipeptidylpeptidase IV Inhibitor IV, K579 (CAS 440100-64-1) References
- K579, a slow-binding inhibitor of dipeptidyl peptidase IV, is a long-acting hypoglycemic agent. | Takasaki, K., et al. 2004. Eur J Pharmacol. 486: 335-42. PMID: 14985056
- Effects of combination treatment with dipeptidyl peptidase IV inhibitor and sulfonylurea on glucose levels in rats. | Takasaki, K., et al. 2004. J Pharmacol Sci. 95: 291-3. PMID: 15215655
- Involvement of the active metabolites in the inhibitory activity of K579 on rat plasma dipeptidyl peptidase IV. | Takasaki, K., et al. 2004. Eur J Pharmacol. 505: 237-41. PMID: 15556158
Inhibitor of:
CD26, and Protease.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Dipeptidylpeptidase IV Inhibitor IV, K579, 5 mg | sc-202583 | 5 mg | $235.00 |