MF: C16H12O6 MW: 300.27 A flavonoid that impedes human CYP1A enzyme activity and has anti-mutagenic and anti-allergenic properties.
Diosmetin (CAS 520-34-3)
Luteolin 4'-methyl ether; 4'-Methylluteolin
Diosmetin is a flavonoid that impedes human CYP1A enzyme activity and has anti-mutagenic and anti-allergenic properties
C 16H 12O 6
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use. *
Certificate of Analysis for lot specific data (including water content).
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Diosmetin is a natural flavonoid that impedes human CYP1A enzyme activity. Diosmetin has anti-mutagenic and anti-allergic characteristic.
1. Huang, M.T., et al. 1983. Carcinogenesis. 4: 1631-1637. PMID: 6360409
2. Cheong, H., et al. 1998. Arch. Pharm. Res. 21: 478-480. PMID: 9875480
Soluble in water (<1 mg/ml at 25° C), acetonitrile, DMSO (60 mg/ml at 25° C), and ethanol (17 mg/ml at 25° C).
~576.7° C at 760 mmHg (Predicted)
20 D 1.70 (Predicted)
50 = 29 nM (human); ABCC1: IC 50 = 140 nM (human); CYP1A2: IC 50 = 2.44 µM (human); MRP1: IC 50 = 3 µM (human); MRP2: IC 50 >50 µM (human)
i= 16 nM (human); ABCC1: K i= 89 nM (human)
a: 6.5 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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Rated 5 out of
Huang et al
Huang et al. (PubMed ID 6360409) used diosmetin to inhibit S. typhimurium mutagenic activity. -SCBT Publication Review
Date published: 2015-03-06
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