Diosmetin CAS: 520-34-3
MF: C16H12O6
MW: 300.27
A flavonoid that impedes human CYP1A enzyme activity and has anti-mutagenic and anti-allergenic properties.

Diosmetin (CAS 520-34-3)

Diosmetin | CAS 520-34-3 is rated 5.0 out of 5 by 1.
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Alternate Names: Luteolin 4'-methyl ether; 4'-Methylluteolin
Application: Diosmetin is a flavonoid that impedes human CYP1A enzyme activity and has anti-mutagenic and anti-allergenic properties
CAS Number: 520-34-3
Purity: ≥98%
Molecular Weight: 300.27
Molecular Formula: C16H12O6
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

Diosmetin is a natural flavonoid that impedes human CYP1A enzyme activity. Diosmetin has anti-mutagenic and anti-allergic characteristic.


References

1. Huang, M.T., et al. 1983. Carcinogenesis. 4: 1631-1637. PMID: 6360409
2. Cheong, H., et al. 1998. Arch. Pharm. Res. 21: 478-480. PMID: 9875480

Physical State :
Solid
Solubility :
Soluble in water (<1 mg/ml at 25° C), acetonitrile, DMSO (60 mg/ml at 25° C), and ethanol (17 mg/ml at 25° C).
Storage :
Store at 4° C
Melting Point :
257-259° C
Boiling Point :
~576.7° C at 760 mmHg (Predicted)
Density :
~1.5 g/cm3 (Predicted)
Refractive Index :
n20D 1.70 (Predicted)
IC50 :
CYP1B1: IC50 = 29 nM (human); ABCC1: IC50 = 140 nM (human); CYP1A2: IC50 = 2.44 µM (human); MRP1: IC50 = 3 µM (human); MRP2: IC50 >50 µM (human)
Ki Data :
CYP1B1: Ki= 16 nM (human); ABCC1: Ki= 89 nM (human)
pK Values :
pKa: 6.5 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
5281612
Merck Index :
14: 3296
MDL Number :
MFCD00017425
EC Number :
208-291-8
Beilstein Registry :
294492
SMILES :
COC1=C(C=C(C=C1)C2=CC(=O)C3=C(C=C(C=C3O2)O)O)O

Download SDS (MSDS)

Certificate of Analysis

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Rated 5 out of 5 by from Huang et al Huang et al. (PubMed ID 6360409) used diosmetin to inhibit S. typhimurium mutagenic activity. -SCBT Publication Review
Date published: 2015-03-06
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