Dio-1 Antibody (C-10): sc-393453
- Dio-1 Antibody (C-10) is a mouse monoclonal mouse IgM κ κ provided at 200 µg/ml
- specific for an epitope mapping between amino acids 553-578 near the C-terminus of Dio-1 of mouse origin
- recommended for detection of Dio-1 of mouse and rat origin by WB, IP, IF and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Dio-1 Antibody (C-10). This work is in progress.
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Dio-1 Antibody (C-10) is a mouse monoclonal IgM antibody that detects Dio-1 in mouse and rat samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Dio-1, also known as Death Inducer-Obliterator-1, is a putative transcription factor characterized by two zinc finger motifs, which are crucial for DNA-binding ability and transcriptional regulation. anti-Dio-1 antibody (C-10) plays a significant role in studying apoptosis, particularly during limb development, where Dio-1 translocates to the nucleus to activate programmed cell death. The regulation of apoptosis is vital for shaping and defining digits, ensuring correct tissue presence. Dio-1 expression notably increases in response to apoptotic signals, paralleling the behavior of other key proteins like NFκB and NGF. Furthermore, Dio-1 activity is modulated by caspase inhibitors and Bcl-2, highlighting its essential function in initiating programmed cell death. Dio-1 (C-10) antibody serves as an invaluable tool for researchers studying apoptosis mechanisms and their implications in developmental biology and disease.
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Dio-1 Antibody (C-10) References:
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- Effects of age and soybean isoflavones on hepatic cholesterol metabolism and thyroid hormone availability in acyclic female rats. | Šošić-Jurjević, B., et al. 2017. Exp Gerontol. 92: 74-81. PMID: 28336316
- Maternal and placental responses before preterm birth: adaptations to increase fetal thyroid hormone availability? | Eerdekens, A., et al. 2019. J Matern Fetal Neonatal Med. 32: 2746-2757. PMID: 29557697
- Phenanthrenes from Eulophia macrobulbon as Novel Phosphodiesterase-5 Inhibitors. | Temkifthawon, P., et al. 2017. Nat Prod Commun. 12: 79-82. PMID: 30549830
- Prognostic Significance of Sodium Iodide Symporter and Deiodinase Enzymes mRNA Expression in Gastric Cancer. | Mishra, A. and Shrivastava, A. 2020. Int J Appl Basic Med Res. 10: 43-48. PMID: 32002385
- Mixing states of imidazolium-based ionic liquid, [C4mim][TFSI], with cycloethers studied by SANS, IR, and NMR experiments and MD simulations. | Kawano, M., et al. 2020. Phys Chem Chem Phys. 22: 5332-5346. PMID: 32096511
- An Urban Intelligence Architecture for Heterogeneous Data and Application Integration, Deployment and Orchestration. | Silvestri, S., et al. 2024. Sensors (Basel). 24: PMID: 38610587
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Dio-1 Antibody (C-10) | sc-393453 | 200 µg/ml | $316.00 | |||
Dio-1 (C-10) Neutralizing Peptide | sc-393453 P | 100 µg/0.5 ml | $68.00 |