Molecular structure of Diminutol, CAS Number: 361431-33-6
Diminutol (CAS 361431-33-6)
Alternate Names:
NG72
Application:
Diminutol is a cell-permeable purine analog that inhibits NQ01 and blocks mitotic spindle assembly
CAS Number:
361431-33-6
Purity:
≥95%
Molecular Weight:
386.51
Molecular Formula:
C19H26N6OS
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Diminutol is a cell-permeable 2,6,9-trisubstituted purine analog that blocks mitotic spindle assembly by competitively inhibiting NQO1, an NADP-dependent oxidoreductase. Diminutol may act to interact with the NADP binding site and directly affect tubulin polymerization. Diminutol does not induce oxidative stress or affect the activity of Cdk1, DNA replication, or actin polymerization. Diminutol may act to cause significant microtubule depolymerization in Xenopus XL177 cells at 50muM.
Diminutol (CAS 361431-33-6) References
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- Nuclear Factor E2-Related Factor-2 Negatively Regulates NLRP3 Inflammasome Activity by Inhibiting Reactive Oxygen Species-Induced NLRP3 Priming. | Liu, X., et al. 2017. Antioxid Redox Signal. 26: 28-43. PMID: 27308893
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Inhibitor of:
NQO1.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Diminutol, 5 mg | sc-203923 | 5 mg | $373.00 |