Diminutol is a cell-permeable 2,6,9-trisubstituted purine analog that blocks mitotic spindle assembly by competitively inhibiting NQO1, an NADP-dependent oxidoreductase. Diminutol has been shown to interact with the NADP binding site and directly affect tubulin polymerization. Diminutol does not induce oxidative stress or affect the activity of Cdk1, DNA replication, or actin polymerization. Diminutol has been shown to cause significant microtubule depolymerization in Xenopus XL177 cells at 50μM.
1. Wignall, Sarah M., et al., 2004. Identification of a novel protein regulating microtubule stability through a chemical approach. Chemistry & biology. 11(1): 135-46. PMID: 15113003
Soluble in DMSO, methanol, and chloroform.
Store at -20° C
633.2° C at 760 mmHg (Predicted)
1.34 g/cm3 (Predicted)
n20D 1.68 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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Wignall et alWignall et al. (PubMed ID 15113003) found that affinity chromatography with Diminutol elucidated NQO1's role in microtubule polymerization activation in a Xenopus egg extract assay. -SCBT Publication Review
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