Diminutol CAS: 361431-33-6
MF: C19H26N6OS
MW: 386.51
A cell-permeable purine analog that inhibits NQ01 and blocks mitotic spindle assembly.

Diminutol (CAS 361431-33-6)

Diminutol | CAS 361431-33-6 is rated 5.0 out of 5 by 1.
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Alternate Names: NG72
Application: Diminutol is a cell-permeable purine analog that inhibits NQ01 and blocks mitotic spindle assembly
CAS Number: 361431-33-6
Purity: ≥95%
Molecular Weight: 386.51
Molecular Formula: C19H26N6OS
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

Diminutol is a cell-permeable 2,6,9-trisubstituted purine analog that blocks mitotic spindle assembly by competitively inhibiting NQO1, an NADP-dependent oxidoreductase. Diminutol has been shown to interact with the NADP binding site and directly affect tubulin polymerization. Diminutol does not induce oxidative stress or affect the activity of Cdk1, DNA replication, or actin polymerization. Diminutol has been shown to cause significant microtubule depolymerization in Xenopus XL177 cells at 50μM.


References

1. Wignall, Sarah M., et al., 2004. Identification of a novel protein regulating microtubule stability through a chemical approach. Chemistry & biology. 11(1): 135-46. PMID: 15113003

Physical State :
Solid
Solubility :
Soluble in DMSO, methanol, and chloroform.
Storage :
Store at -20° C
Melting Point :
152° C
Boiling Point :
633.2° C at 760 mmHg (Predicted)
Density :
1.34 g/cm3 (Predicted)
Refractive Index :
n20D 1.68 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
16760403
MDL Number :
MFCD23160286
SMILES :
CC(C)[[email protected]](CO)NC1=NC2=C(C(=N1)SC3=CC=CC(=C3)N)N=CN2C(C)C

Download SDS (MSDS)

Certificate of Analysis

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Rated 5 out of 5 by from Wignall et al Wignall et al. (PubMed ID 15113003) found that affinity chromatography with Diminutol elucidated NQO1's role in microtubule polymerization activation in a Xenopus egg extract assay. -SCBT Publication Review
Date published: 2015-07-10
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