Date published: 2026-4-24

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Dimethylisopropylsilane (CAS 18209-61-5)

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CAS Number:
18209-61-5
Molecular Weight:
102.25
Molecular Formula:
C5H14Si
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Dimethylisopropylsilane is a chemical compound that functions as a silylating agent in organic synthesis. It acts as a protecting group for alcohols and amines, allowing for selective reactions in the presence of other functional groups. Dimethylisopropylsilane is used to block specific reactive sites on molecules, preventing unwanted side reactions during the synthesis. Dimethylisopropylsilane achieves this by forming stable silyl ethers or silyl amines, which can be easily removed under mild conditions when the desired reactions are complete. Its mechanism of action involves the transfer of the silyl group to the hydroxyl or amino group of the target molecule, leading to the formation of the protective silyl derivative.


Dimethylisopropylsilane (CAS 18209-61-5) References

  1. Novel derivatization and immunoextraction to improve microanalysis of 11-dehydrothromboxane B2 in human urine.  |  Ishibashi, M., et al. 1991. J Chromatogr. 562: 613-24. PMID: 2026724
  2. Microdetermination of 11-dehydrothromboxane B2 in human urine by gas chromatography-selected-ion monitoring.  |  Watanabe, K., et al. 1989. J Chromatogr. 468: 383-94. PMID: 2732290
  3. Microdetermination of 2,3-dinor-6-ketoprostaglandin F1 alpha in human urine using gas chromatography-high-resolution selected-ion monitoring.  |  Mizugaki, M., et al. 1994. J Chromatogr B Biomed Appl. 658: 11-9. PMID: 7952110
  4. Analysis of 11-dehydrothromboxane B2 in human urine improved by use of gas chromatography/high-resolution selected ion monitoring with 18O2-labelled analogue as an internal standard.  |  Ishibashi, M., et al. 1994. Biol Mass Spectrom. 23: 612-20. PMID: 7986831
  5. Identification of 11-dehydro-2,3-dinorthromboxane B3 in human urine based on the mass spectral properties of 11-dehydrothromboxane B3 and related compounds.  |  Ishibashi, M., et al. 1995. Rapid Commun Mass Spectrom. Spec No: S116-22. PMID: 8829476
  6. Dimethylisopropylsilyl ether derivatives in gas chromatography mass spectrometry of prostaglandins and thromboxane B2†  |  Hiroshi Miyazaki, Masataka Ishibashi, Kouwa Yamashita, Yuko Nishikawa, Makoto Katori. 1981. Biomedical Mass Spectrometry. 8: 521-526.

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Dimethylisopropylsilane, 1 g

sc-227909
1 g
$53.00