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Diltiazem hydrochloride (CAS 33286-22-5)

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Alternate Names:
(+)-cis-Diltiazem hydrochlorid
Application:
Diltiazem hydrochloride is a calcium channel protein inhibitor
CAS Number:
33286-22-5
Purity:
≥98%
Molecular Weight:
451.0
Molecular Formula:
C22H26N2O4S•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Diltiazem hydrochloride is widely used in cardiovascular research, particularly for its effects on calcium channels. This compound acts as a calcium channel blocker, making it useful for studying the regulation of calcium influx in cardiac and smooth muscle cells. Research involving Diltiazem hydrochloride often focuses on providing insights into the mechanisms of cardiac muscle relaxation and contraction. Additionally, Diltiazem hydrochloride is employed in studies exploring vascular smooth muscle behavior, helping to elucidate how calcium channel activity affects vascular tone and resistance. Moreover, this compound is used in electrophysiological studies to investigate the effects of calcium channel modulation on electrical activity within the heart, aiding in the understanding of arrhythmogenesis and other electrical disturbances in the cardiac system.


Diltiazem hydrochloride (CAS 33286-22-5) References

  1. The effects of verapamil and diltiazem on N-, P- and Q-type calcium channels mediating dopamine release in rat striatum.  |  Dobrev, D., et al. 1999. Br J Pharmacol. 127: 576-82. PMID: 10385261
  2. Diltiazem causes open channel block of recombinant 5-HT3 receptors.  |  Gunthorpe, MJ. and Lummis, SC. 1999. J Physiol. 519 Pt 3: 713-22. PMID: 10457085
  3. Calcium channels--basic aspects of their structure, function and gene encoding; anesthetic action on the channels--a review.  |  Yamakage, M. and Namiki, A. 2002. Can J Anaesth. 49: 151-64. PMID: 11823393
  4. [Preparation of diltiazem hydrochloride delayed-onset, sustained release tablet].  |  Zhang, N. and Zhu, JB. 2002. Yao Xue Xue Bao. 37: 724-7. PMID: 12567900
  5. International Union of Pharmacology. XLVIII. Nomenclature and structure-function relationships of voltage-gated calcium channels.  |  Catterall, WA., et al. 2005. Pharmacol Rev. 57: 411-25. PMID: 16382099
  6. Influence of plasticizer level on the drug release from sustained release film coated and hot-melt extruded dosage forms.  |  Zhu, Y., et al. 2006. Pharm Dev Technol. 11: 285-94. PMID: 16895839
  7. Calcium antagonism and calcium entry blockade.  |  Godfraind, T., et al. 1986. Pharmacol Rev. 38: 321-416. PMID: 2432624
  8. Stereospecific action of diltiazem on the mitochondrial Na-Ca exchange system and on sarcolemmal Ca-channels.  |  Chiesi, M., et al. 1987. Biochem Pharmacol. 36: 2735-40. PMID: 2443142
  9. Some variables affecting the characteristics of Eudragit E-sodium alginate polyelectrolyte complex as a tablet matrix for diltiazem hydrochloride.  |  Yusif, RM., et al. 2014. Acta Pharm. 64: 89-104. PMID: 24670354
  10. A Zebrafish Thrombosis Model for Assessing Antithrombotic Drugs.  |  Zhu, XY., et al. 2016. Zebrafish. 13: 335-44. PMID: 27333081
  11. [Effect and mechanism of Huangqi Shengmai Decoction in treatment of joint rat model of fatigue and myocardial injury].  |  Yuan, YH., et al. 2022. Zhongguo Zhong Yao Za Zhi. 47: 5292-5298. PMID: 36472036
  12. Organic phosphorus compounds. 1. 4-(Benzothiazol-2-yl)benzylphosphonate as potent calcium antagonistic vasodilator.  |  Yoshino, K., et al. 1986. J Med Chem. 29: 820-5. PMID: 3701791
  13. pH-dependent block of the L-type Ca2+ channel current by diltiazem in human mesenteric arterial myocytes.  |  Smirnov, SV. and Aaronson, PI. 1998. Eur J Pharmacol. 360: 81-90. PMID: 9845276

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Diltiazem hydrochloride, 1 g

sc-200199
1 g
$39.00

Diltiazem hydrochloride, 5 g

sc-200199A
5 g
$153.00

Diltiazem hydrochloride, 10 g

sc-200199B
10 g
$224.00

Diltiazem hydrochloride, 50 g

sc-200199C
50 g
$510.00

Diltiazem hydrochloride, 100 g

sc-200199D
100 g
$918.00

Diltiazem hydrochloride, 500 g

sc-200199E
500 g
$2295.00

Diltiazem hydrochloride, 1 kg

sc-200199F
1 kg
$4080.00

How to calculate the solubility in diltiazem HCl

Asked by: vijayj
Thank you for your question. This chemical is soluble in water (50 mg/ml), methanol, formic acid, ethanol, chloroform, and DMSO (100 mM).
Answered by: Technical Support
Date published: 2018-12-21
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Rated 5 out of 5 by from NaplesNaples, JG. et al. (PubMed 26419839) reported that intratympanic Diltiazem, a calcium channel protein inhibitor, has significant protective effects against cisplatin-induced ototoxicity in mice. -SCBT Publication Review
Date published: 2015-01-11
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Diltiazem hydrochloride | CAS 33286-22-5 is rated 5.0 out of 5 by 1.
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