Diltiazem hydrochloride CAS: 33286-22-5
MF: C22H26N2O4S•HCl
MW: 451.0
A calcium channel protein inhibitor.

Diltiazem hydrochloride (CAS 33286-22-5)

Diltiazem hydrochloride | CAS 33286-22-5 is rated 5.0 out of 5 by 1.
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Alternate Names: (+)-cis-Diltiazem hydrochlorid
Application: Diltiazem hydrochloride is a calcium channel protein inhibitor
CAS Number: 33286-22-5
Purity: ≥98%
Molecular Weight: 451.0
Molecular Formula: C22H26N2O4S•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

Diltiazem hydrochloride is an antihypertensive and cardioprotective agent as well as a calcium channel protein inhibitor. It inhibits L-type Ca2+ channels and regulates Ca2+ release from intracellular stores in neutrophils.


References

1. Chiesi, M., et al. 1987. Biochem. Pharmacol 36: 2735-2740. PMID: 2443142
2. Godfraind, T., et al. 1986. Pharmacol. Rev. 38: 321-416. PMID: 2432624
3. Gunthorpe, M.J. and Lummis, S.C. 1999. J. Physiol. 519: 713-722. PMID: 10457085
4. Dobrev, D., et al. 1999. Br. J. Pharmacol. 127: 576-582. PMID: 10385261
5. Smirnov, S.V. and Aaronson, P.I. 1998. Eur. J. Pharmacol. 360: 81-90. PMID: 9845276
6. Catterall, W.A., et al. 2005. Pharmacol. Rev. 57: 411-425. PMID: 16382099
7. Yamakage, M. and Namiki, A. 2002. Can J Anaesth. 49: 151-164. PMID: 11823393

Appearance :
Crystalline powder
Physical State :
Solid
Solubility :
Soluble in water (50 mg/ml), methanol, formic acid, ethanol, chloroform, and DMSO (100 mM).
Storage :
Store at room temperature
Melting Point :
212° C
Optical Activity :
α20/D 118°, c = 1 in water; α20/D +101°, c = 1 in methanol
IC50 :
JC polyomavirus M1/SVEdelta: EC5050 = 8500 nM (human SVG-A cells)
pK Values :
pKb: 8.94
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
DL0310000
PubChem CID :
62920
Merck Index :
14: 3202
MDL Number :
MFCD00069252
EC Number :
251-443-3
Beilstein Registry :
4228706
SMILES :
CC(=O)O[[email protected]@H]1[[email protected]@H](SC2=CC=CC=C2N(C1=O)CCN(C)C)C3=CC=C(C=C3)OC.Cl

Download SDS (MSDS)

Certificate of Analysis

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How to calculate the solubility in diltiazem HCl

Asked by: vijayj
Thank you for your question. This chemical is soluble in water (50 mg/ml), methanol, formic acid, ethanol, chloroform, and DMSO (100 mM).
Answered by: Technical Support
Date published: 2018-12-21
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Rated 5 out of 5 by from Naples Naples, JG. et al. (PubMed 26419839) reported that intratympanic Diltiazem, a calcium channel protein inhibitor, has significant protective effects against cisplatin-induced ototoxicity in mice. -SCBT Publication Review
Date published: 2015-01-11
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