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Dilazep dihydrochloride (CAS 20153-98-4)

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Alternate Names:
1,4-bis[3-(3,4,5-Trimethoxybenzoyloxy)propyl]homopiperazine dihydrochloride; ASTA C 4898; Cormelian
Application:
Dilazep dihydrochloride is an adenosine uptake inhibitor
CAS Number:
20153-98-4
Molecular Weight:
677.62
Molecular Formula:
C31H44N2O102HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Dilazep dihydrochloride is an adenosine uptake inhibitor. Dilazep dihydrochloride inhibits platelet aggregation and membrane transport of nucleosides. Dilazep dihydrochloride suppresses the effects of ischemia and acts as a coronary and cerebral vasodilator. For decades, scientists have harnessed the potency and adaptability of Dilazep dihydrochloride, a robust compound renowned for its multifaceted applications in scientific exploration. As a polycyclic aromatic hydrocarbon (PAH), Cormelian finds its utility across a spectrum of both in vivo and in vitro investigations. Its participation spans various realms of biological and biochemical scrutiny. While the precise modus operandi of Dilazep dihydrochloride remains partially veiled, it is postulated that the compound engages specific cellular receptors upon their surface. This engagement acts as the catalyst, initiating a series of intricate biochemical responses that culminate in the sought-after biological effects.


Dilazep dihydrochloride (CAS 20153-98-4) References

  1. Effect of dilazep dihydrochloride on plasma P-selectin concentrations in patients with IgA nephropathy.  |  Ebihara, I., et al. 2000. Nephron. 85: 281-2. PMID: 10867547
  2. Effect of dilazep dihydrochloride on urinary albumin excretion in patients with autosomal dominant polycystic kidney disease.  |  Nakamura, T., et al. 2001. Nephron. 88: 80-2. PMID: 11340355
  3. Dilazep dihydrochloride prolongs the infarct size-limiting effect of ischemic preconditioning in rabbits.  |  Yamasaki, K., et al. 2000. Heart Vessels. 15: 227-32. PMID: 11560359
  4. Effect of dilazep dihydrochloride on serum cardiac troponin T levels in hemodialysis patients.  |  Nakamura, T., et al. 2002. Kidney Blood Press Res. 25: 50-4. PMID: 11834877
  5. Combination AST-120 and dilazep dihydrochloride therapy reduced urinary protein excretion and serum creatinine levels in patients with chronic renal failure.  |  Nakamura, T., et al. 2002. Ren Fail. 24: 683-5. PMID: 12380917
  6. Silent cerebral infarction in patients with type 2 diabetic nephropathy. Effects of antiplatelet drug dilazep dihydrochloride.  |  Nakamura, T., et al. 2005. Diabetes Metab Res Rev. 21: 39-43. PMID: 15386824
  7. Effect of dilazep dihydrochloride against ischemia and reperfusion-induced disruption of blood-brain barrier in rats: a quantitative study.  |  Kawagoe, J., et al. 1992. Naunyn Schmiedebergs Arch Pharmacol. 345: 485-8. PMID: 1620248
  8. Dilazep potentiation of adenosine-mediated superior mesenteric arterial vasodilation.  |  Zhang, Y., et al. 1991. J Pharmacol Exp Ther. 258: 767-71. PMID: 1890619
  9. Dilazep decreases lipopolysaccharide-induced nitric oxide and TNF-alpha synthesis in RAW 264 cells.  |  Nakatsuka, R., et al. 2010. J Pharmacol Sci. 113: 271-5. PMID: 20647687
  10. Effects of combination therapy with renin-angiotensin system inhibitors and eicosapentaenoic acid on IgA nephropathy.  |  Moriyama, T., et al. 2013. Intern Med. 52: 193-9. PMID: 23318848
  11. Therapeutic tolerance, hemodynamic effects, and oral dose kinetics of dilazep dihydrochloride in hypertensive patients.  |  Sambhi, MP., et al. 1989. J Pharm Sci. 78: 281-4. PMID: 2724090
  12. Effects of dilazep dihydrochloride (Dilazep) and its dose-dependent influence on rabbit acute serum sickness nephritis.  |  Inage, H., et al. 1985. Nihon Jinzo Gakkai Shi. 27: 1253-60. PMID: 4087546
  13. Effects of antiplatelet drug dilazep dihydrochloride on anionic sites and extracellular matrix (ECM) components in glomerular basement membrane of STZ-induced diabetic rats.  |  Yamamoto, M., et al. 1995. J Clin Lab Anal. 9: 380-6. PMID: 8587006

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Dilazep dihydrochloride, 50 mg

sc-203566
50 mg
$306.00