Date published: 2025-9-29

1-800-457-3801

SCBT Portrait Logo
Seach Input

Diisopropylammonium dichloroacetate (CAS 660-27-5)

0.0(0)
Write a reviewAsk a question

Alternate Names:
Vasculopatina; Dipromonium
CAS Number:
660-27-5
Molecular Weight:
230.13
Molecular Formula:
C2H2Cl2O2•C6H15N
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

QUICK LINKS

Diisopropylammonium dichloroacetate (DIPDA) is an extensively studied organic compound that holds significant potential for scientific applications. Comprising two isopropyl groups and two chlorine atoms, it functions as a quaternary ammonium salt. Diisopropylammonium dichloroacetate exhibits a range of unique properties, making it highly attractive for various scientific and medical investigations. Diisopropylammonium dichloroacetate finds diverse applications in scientific research. Diisopropylammonium dichloroacetate acts as a catalyst in organic synthesis and as a reagent in polymer synthesis. Although the precise mechanism of action of Diisopropylammonium dichloroacetate remains incompletely understood, it is believed that the presence of the quaternary ammonium salt structure enables its interaction with various biological molecules, encompassing proteins, nucleic acids, and lipids. This interaction is thought to underlie the diverse biological activities associated with Diisopropylammonium dichloroacetate.


Diisopropylammonium dichloroacetate (CAS 660-27-5) References

  1. [Experimental research on the action of diisopropylammonium dichloroacetate in burn shock].  |  MARULLO, U. and D'ANGELO, A. 1962. Riv Patol Clin. 17: 294-302. PMID: 13933192
  2. Diisopropylamine dichloroacetate, a novel pyruvate dehydrogenase kinase 4 inhibitor, as a potential therapeutic agent for metabolic disorders and multiorgan failure in severe influenza.  |  Yamane, K., et al. 2014. PLoS One. 9: e98032. PMID: 24865588
  3. Energy metabolic disorder is a major risk factor in severe influenza virus infection: Proposals for new therapeutic options based on animal model experiments.  |  Kido, H., et al. 2016. Respir Investig. 54: 312-9. PMID: 27566378
  4. Superior anti-tumor efficacy of diisopropylamine dichloroacetate compared with dichloroacetate in a subcutaneous transplantation breast tumor model.  |  Su, L., et al. 2016. Oncotarget. 7: 65721-65731. PMID: 27582548
  5. Diisopropylamine dichloroacetate enhances radiosensitization in esophageal squamous cell carcinoma by increasing mitochondria-derived reactive oxygen species levels.  |  Dong, G., et al. 2016. Oncotarget. 7: 68170-68178. PMID: 27626688
  6. Antioxidant influence on poultry liver morphology and hepatocyte ultrastructure.  |  Skovorodin, E., et al. 2019. Vet World. 12: 1716-1728. PMID: 32009750
  7. Targeting Glucose Metabolism of Cancer Cells with Dichloroacetate to Radiosensitize High-Grade Gliomas.  |  Cook, KM., et al. 2021. Int J Mol Sci. 22: PMID: 34298883
  8. Cobalt-conjugated carbon quantum dots for in vivo monitoring of the pyruvate dehydrogenase kinase inhibitor drug dichloroacetic acid.  |  Raut, J., et al. 2022. Sci Rep. 12: 19366. PMID: 36371411
  9. Diisopropylammonium dichloroacetate (DIPA) and sodium dichloracetate (DCA): effect on glucose and fat metabolism in normal and diabetic tissue.  |  Stacpoole, PW. and Felts, JM. 1970. Metabolism. 19: 71-8. PMID: 4244198
  10. Review of the pharmacologic and therapeutic effects of diisopropylammonium dichloroacetate (DIPA).  |  Stacpoole, PW. 1969. J Clin Pharmacol J New Drugs. 9: 282-91. PMID: 4902026
  11. Diisopropylammonium dichloroacetate (DIPA): reversible antagonism towards smooth muscle stimulants and inhibition of acetylcholinesterase in the isolated guinea pig ileum.  |  Stacpoole, PW., et al. 1971. Res Commun Chem Pathol Pharmacol. 2: 439-46. PMID: 5139065
  12. Effects of diisopropylammonium dichloroacetate on glucose metabolism.  |  Stacpoole, PW. and Felts, JM. 1969. Proc West Pharmacol Soc. 12: 111-3. PMID: 5812282
  13. Mutagenicity of diisopropylamine dichloroacetate, the 'active constituent' of vitamin B15 (pangamic acid).  |  Gelernt, MD. and Herbert, V. 1982. Nutr Cancer. 3: 129-33. PMID: 6752894

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Diisopropylammonium dichloroacetate, 250 mg

sc-495460
250 mg
$58.00