Dihydrosphingosine-1-phosphate, D-erythro is a saturated analog of sphingosine-1-phosphate. Dihydrosphingosine-1-phosphate, D-erythro also induces chemotaxis in HUVECs1. May be used as a negative control for intracellular effects of S1P2. Dihydrosphingosine-1-phosphate, D-erythro is rapidly dephosphorylated by a sphingosine phosphatase in cultured human fibroblasts3. Ligand for S1P (EDG) receptors.
1: F. Wang et al. J. Biol. Chem. 1999 274 35343 2: A. Berger et al. Mol. Pharmacol. 1996 50 451 3: P.P. van Veldhoven and G.P. Mannaerts Biochem. J. 1994 299 597 4: J.R. Van Brooklyn et al. J. Biol. Chem. 1999 274 4626
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