Dihydrosphingosine-1-phosphate, D-erythro (CAS 28508-07-8)
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Dihydrosphingosine-1-phosphate, D-erythro, is a sphingolipid metabolite that has significant interest in cell signaling and sphingolipid metabolism studies. As a sphingosine-1-phosphate (S1P) analog, this compound is utilized in research to elucidate the signaling pathways mediated by S1P receptors, which play key roles in cell proliferation, survival, migration, and angiogenesis. It is involved in the sphingolipid rheostat balance, a dynamic equilibrium between ceramides, sphingosine, and their phosphorylated forms, which is for determining cell fate. In cellular studies, Dihydrosphingosine-1-phosphate, D-erythro, is used to investigate its effects on intracellular calcium mobilization, cytoskeletal rearrangement, and endothelial barrier integrity. Additionally, it serves as a tool in the exploration of sphingosine kinase activity, the enzyme responsible for its formation, to better understand lipid signaling mechanisms.
Dihydrosphingosine-1-phosphate, D-erythro (CAS 28508-07-8) References
- In vitro autoradiographic visualization of guanosine-5'-O-(3-[35S]thio)triphosphate binding stimulated by sphingosine 1-phosphate and lysophosphatidic acid. | Waeber, C. and Chiu, ML. 1999. J Neurochem. 73: 1212-21. PMID: 10461914
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Dihydrosphingosine-1-phosphate, D-erythro, 1 mg | sc-223941 | 1 mg | $142.00 |