Molecular structure of Dihydromethysticin, CAS Number: 3155-57-5
Dihydromethysticin (CAS 3155-57-5)
Application:
Dihydromethysticin is a neuroprotective and antinociceptive kava lactone
CAS Number:
3155-57-5
Purity:
≥98%
Molecular Weight:
276.28
Molecular Formula:
C15H16O5
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Dihydromethysticin is a kavalactone found in the roots of the kava plant, which is studied extensively for its unique structure and effects on the central nervous system in research applications. In the field of neuroscience, it is of particular interest for its potential modulatory effects on neuroreceptors and ion channels. Biochemists explore the compound′s interaction with GABA, dopamine, and serotonin receptors to advance the understanding of neurological pathways and receptor dynamics. In synthetic organic chemistry, the challenges associated with replicating the stereochemistry of dihydromethysticin drive the development of novel asymmetric synthesis techniques.
Dihydromethysticin (CAS 3155-57-5) References
- Extract of kava (Piper methysticum) and its methysticin constituents protect brain tissue against ischemic damage in rodents. | Backhauss, C. and Krieglstein, J. 1992. Eur J Pharmacol. 215: 265-9. PMID: 1396990
- Desmethoxyyangonin and dihydromethysticin are two major pharmacological kavalactones with marked activity on the induction of CYP3A23. | Ma, Y., et al. 2004. Drug Metab Dispos. 32: 1317-24. PMID: 15282211
- The antinociceptive actions of kava components in mice. | Jamieson, DD. and Duffield, PH. 1990. Clin Exp Pharmacol Physiol. 17: 495-507. PMID: 2401103
- Dihydromethysticin from kava blocks tobacco carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced lung tumorigenesis and differentially reduces DNA damage in A/J mice. | Narayanapillai, SC., et al. 2014. Carcinogenesis. 35: 2365-72. PMID: 25053626
- Flavokawains a and B in kava, not dihydromethysticin, potentiate acetaminophen-induced hepatotoxicity in C57BL/6 mice. | Narayanapillai, SC., et al. 2014. Chem Res Toxicol. 27: 1871-6. PMID: 25185080
- Dihydromethysticin kavalactone induces apoptosis in osteosarcoma cells through modulation of PI3K/Akt pathway, disruption of mitochondrial membrane potential and inducing cell cycle arrest. | Dai, JQ., et al. 2015. Int J Clin Exp Pathol. 8: 4356-66. PMID: 26191127
- Dihydromethysticin (DHM) Blocks Tobacco Carcinogen 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)-Induced O6-Methylguanine in a Manner Independent of the Aryl Hydrocarbon Receptor (AhR) Pathway in C57BL/6 Female Mice. | Narayanapillai, SC., et al. 2016. Chem Res Toxicol. 29: 1828-1834. PMID: 27728767
- Dihydromethysticin, a natural molecule from Kava, suppresses the growth of colorectal cancer via the NLRC3/PI3K pathway. | Pan, H., et al. 2020. Mol Carcinog. 59: 575-589. PMID: 32187756
- Oral Dosing of Dihydromethysticin Ahead of Tobacco Carcinogen NNK Effectively Prevents Lung Tumorigenesis in A/J Mice. | Hu, Q., et al. 2020. Chem Res Toxicol. 33: 1980-1988. PMID: 32476407
- In vivo Structure-Activity Relationship of Dihydromethysticin in Reducing Nicotine-Derived Nitrosamine Ketone (NNK)-Induced Lung DNA Damage against Lung Carcinogenesis in A/J Mice. | Hati, S., et al. 2022. ChemMedChem. 17: e202100727. PMID: 35064644
- Suppressing the activation of protein kinase A as a DNA damage-independent mechanistic lead for dihydromethysticin prophylaxis of NNK-induced lung carcinogenesis. | Bian, T., et al. 2022. Carcinogenesis. 43: 659-670. PMID: 35353881
- Characterization and identification of the metabolites of dihydromethysticin by ultra-high-performance liquid chromatography orbitrap high-resolution mass spectrometry. | Cheng, C., et al. 2022. J Sep Sci. 45: 2914-2923. PMID: 35689602
- Effects of kawain and dihydromethysticin on field potential changes in the hippocampus. | Walden, J., et al. 1997. Prog Neuropsychopharmacol Biol Psychiatry. 21: 697-706. PMID: 9194150
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Dihydromethysticin, 5 mg | sc-204725 | 5 mg | $240.00 | |||
Dihydromethysticin, 10 mg | sc-204725A | 10 mg | $394.00 |