Dihydrokaempferol (CAS 480-20-6)

Dihydrokaempferol is a flavone that has been found in J. chinensis and has diverse biological activities. It scavenges DPPH radicals (IC50 = 2.21 µM) and inhibits acetylcholinesterase (AChE IC50 = 35.43 µM), but not butyrylcholinesterase (BChE) and β-secretase 1 (BACE1 IC50s = >200 µM), in cell-free assays. Dihydrokaempferol inhibits the growth of BT474 breast, ChaGo-K-1 lung, HepG2 liver, KATO III gastric, and SW620 colon cancer cells (IC50s = 11.66, 12.32, 13.67, 39.79, and 41.11 µM, respectively). It prevents cytokine production in anti-CD3 and anti-CD28-stimulated T cells in a concentration-dependent manner Dihydrokaempferol reduces pancreatic damage in a mouse model of caerulin and LPS-induced severe acute pancreatitis in a dose-dependent manner. Within the cell, it is primarily located in the cytoplasm. Dihydrokaempferol participates in a number of enzymatic reactions. In particular, it can be biosynthesized from kaempferol. Dihydrokaempferol can also be converted into 6-methoxyaromadendrin 3-O-acetate and phellamurin. It is found in a number of food items such as loganberry, fenugreek, bog bilberry, and narrowleaf cattail. This makes Dihydrokaempferol a potential biomarker for the consumption of these food products.