Molecular structure of Dihydrofolic acid, CAS Number: 4033-27-6
Dihydrofolic acid (CAS 4033-27-6)
Alternate Names:
7,8-Dihydropteroyl-L-glutamic acid; Dihydropteroyl-L-glutamic acid; FAH2
Application:
Dihydrofolic acid is an intermediate in purine and pyrimidine biosynthesis
CAS Number:
4033-27-6
Purity:
≥90%
Molecular Weight:
443.41
Molecular Formula:
C19H21N7O6
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Dihydrofolic acid is a derivative of Folic acid (sc-204758) with a saturation on the pteridine ring relative to the parent compound. Reduction of Dihydrofolic acid by dihydrofolate reductase produces Tetrahydrofolic acid (sc-215955), an important transformation in the biosynthesis pathway to purines and pyrimidines. Dihydrofolic acid is potentially useful as a reference in studying the inhibition of purine biosynthesis by compounds. Dihydrofolic acid is a substrate of DHFR.
Dihydrofolic acid (CAS 4033-27-6) References
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- Folate requirements of the 2-keto-L-gulonic acid-producing strain Ketogulonigenium vulgare LMP P-20356 in L-sorbose/CSL medium. | Leduc, S., et al. 2004. Appl Microbiol Biotechnol. 65: 163-7. PMID: 15293031
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- Mechanistic insights into folic acid-dependent vascular protection: dihydrofolate reductase (DHFR)-mediated reduction in oxidant stress in endothelial cells and angiotensin II-infused mice: a novel HPLC-based fluorescent assay for DHFR activity. | Gao, L., et al. 2009. J Mol Cell Cardiol. 47: 752-60. PMID: 19660467
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- Controlling enzyme inhibition using an expanded set of genetically encoded amino acids. | Zheng, S. and Kwon, I. 2013. Biotechnol Bioeng. 110: 2361-70. PMID: 23568807
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- The folA gene from the Rickettsia endosymbiont of Ixodes pacificus encodes a functional dihydrofolate reductase enzyme. | Bodnar, JL., et al. 2018. Ticks Tick Borne Dis. 9: 443-449. PMID: 29284564
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- A quantitative metabolomics assay targeting 14 intracellular metabolites associated with the methionine transsulfuration pathway using LC-MS/MS in breast cancer cells. | Jiao, Z., et al. 2022. J Chromatogr B Analyt Technol Biomed Life Sci. 1205: 123314. PMID: 35772357
- The effect of methotrexate on intracellular folate pools in human MCF-7 breast cancer cells. Evidence for direct inhibition of purine synthesis. | Allegra, CJ., et al. 1986. J Biol Chem. 261: 6478-85. PMID: 3700401
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Substrate of:
DHFR.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Dihydrofolic acid, 10 mg | sc-214895 | 10 mg | $163.00 | |||
Dihydrofolic acid, 25 mg | sc-214895A | 25 mg | $302.00 | |||
Dihydrofolic acid, 100 mg | sc-214895B | 100 mg | $1012.00 |