Molecular structure of Dihydroergotamine Methanesulfonate Salt, CAS Number: 6190-39-2
Dihydroergotamine Methanesulfonate Salt (CAS 6190-39-2)
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Alternate Names:
Dihydergot; Dihytamine
Application:
Dihydroergotamine Methanesulfonate Salt is a competitive serotonin antagonist and vasoconstrictor
CAS Number:
6190-39-2
Molecular Weight:
679.8
Molecular Formula:
C33H37N5O5•CH3SO3H
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Dihydroergotamine Methanesulfonate Salt functions as a potent vasoconstrictor. It acts by binding to and activating serotonin receptors, particularly the 5-HT1B and 5-HT1D subtypes, leading to the constriction of blood vessels. This mechanism of action results in the reduction of blood flow in the cranial vessels, which may be relevant in certain experiment. Dihydroergotamine Methanesulfonate Salt has an affinity for dopamine receptors, although its precise role in this interaction is not fully understood.
Dihydroergotamine Methanesulfonate Salt (CAS 6190-39-2) References
- The use of dihydroergotamine methanesulfonate (dhe-45) in shortening labor. | BASKIN, MJ. and CREALOCK, FW. 1951. Rocky Mt Med J. 48: 514-6. PMID: 14854746
- The influence of dihydroergotamine methanesulfonate (DHE-45) on epinephrine induced cardiac irregularities in dogs during anesthesia with several agents. | WHITE, JM., et al. 1951. Arch Int Pharmacodyn Ther. 88: 361-7. PMID: 14934365
- Further experience with dihydroergotamine methanesulfonate in the treatment of migraine; with a note on the use of cafergone. | POLLOCK, LA. 1949. Ann West Med Surg. 3: 388-90. PMID: 15407298
- The management of cervical spasm with dihydroergotamine methanesulfonate (DHE-45). | BASKIN, MJ. and CREALOCK, FW. 1950. West J Surg Obstet Gynecol. 58: 302-7. PMID: 15425106
- Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum. | Yuan, J., et al. 2009. Nat Chem Biol. 5: 765-71. PMID: 19734910
- A pharmacological evaluation of dihydroergotamine methanesulfonate (DHE 45). | ORTH, OS. and RITCHIE, G. 1947. J Pharmacol Exp Ther. 90: 166-73. PMID: 20249078
- Chemical genomics for studying parasite gene function and interaction. | Li, J., et al. 2013. Trends Parasitol. 29: 603-11. PMID: 24215777
- The FDA-approved natural product dihydroergocristine reduces the production of the Alzheimer's disease amyloid-β peptides. | Lei, X., et al. 2015. Sci Rep. 5: 16541. PMID: 26567970
- Machine learning for predicting lifespan-extending chemical compounds. | Barardo, DG., et al. 2017. Aging (Albany NY). 9: 1721-1737. PMID: 28783712
- [Kinetics of the increase in serum levels of beta-endorphin after ingestion of dihydroergotamine methanesulfonate. Influence of the dosage form]. | Kerdelhue, B. 1985. Therapie. 40: 465-8. PMID: 2935963
- [Adrenergic blocking action of dihydroergotamine methanesulfonate (D.H.E.) studied in chloralose-treated dogs]. | De Bonnevaux, SC., et al. 1966. Acta Cient Venez. 17: 6-8. PMID: 5956891
- Effects of dihydroergotamine methanesulfonate on the microcirculation of the rat cremaster muscle. | Sakanashi, M., et al. 1977. Naunyn Schmiedebergs Arch Pharmacol. 301: 83-5. PMID: 600323
- Interspecies similarities in the disposition of 3H-dihydroergotamine following subcutaneous administration in man and rabbits. | Tse, FL. and Jaffe, JM. 1984. Eur J Drug Metab Pharmacokinet. 9: 65-71. PMID: 6714270
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Dihydroergotamine Methanesulfonate Salt, 10 mg | sc-294343 | 10 mg | $42.00 | |||
Dihydroergotamine Methanesulfonate Salt, 25 mg | sc-294343A | 25 mg | $48.00 | |||
Dihydroergotamine Methanesulfonate Salt, 100 mg | sc-294343B | 100 mg | $93.00 |