Molecular structure of Dihydroergocristine mesylate, CAS Number: 24730-10-7
Dihydroergocristine mesylate (CAS 24730-10-7)
See product citations (3)
Alternate Names:
Dihydroergocristinmesilat
Application:
Dihydroergocristine mesylate is an ergot alkaloid serotonin receptor antagonist
CAS Number:
24730-10-7
Purity:
≥98%
Molecular Weight:
707.84
Molecular Formula:
C35H41N5O5•CH3SO3H
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Dihydroergocristine mesylate is a semisynthetic ergot alkaloid with effects on memory and cognition. Dihydroergocristine mesylate demonstrates antagonism at SR (serotonin receptors) and partial agonism/antagonism of dopaminergic and adrenergic receptors. Enhancement of spatial learning, acquisition of avoidance behavior, and retention of passive avoidance response were observed in aged rats exposed to Dihydroergocristine mesylate. Amphoteric vasoregulating activity is also observed with Dihydroergocristine mesylate, where hypotensive effects are noted in hypertensive animals and hypertensive effects noted in hypotensive animals.
Dihydroergocristine mesylate (CAS 24730-10-7) References
- Liquid chromatographic determination of carvedilol in human plasma. | Ptácek, P., et al. 2003. J Chromatogr B Analyt Technol Biomed Life Sci. 789: 405-10. PMID: 12742131
- [Dihydroergocristine. A review of pharmacology and toxicology]. | Coppi, G. 1992. Arzneimittelforschung. 42: 1381-90. PMID: 1492857
- Pharmacokinetics of dihydroergocristine and its major metabolite 8'-hydroxy-dihydroergocristine in human plasma. | Bicalho, B., et al. 2005. Curr Drug Metab. 6: 519-29. PMID: 16379666
- Dihydroergocristine and memory alterations of aged male rats. | Drago, F., et al. 1988. Pharmacol Biochem Behav. 30: 961-5. PMID: 3147464
- DHEC mesylate attenuates pathologies and aberrant bisecting N-glycosylation in Alzheimer's disease models. | Wang, Y., et al. 2024. Neuropharmacology. 248: 109863. PMID: 38325771
- Targeting aberrant glycosylation to modulate microglial response and improve cognition in models of Alzheimer's disease. | Wang, Y., et al. 2024. Pharmacol Res. 202: 107133. PMID: 38458367
Inhibitor of:
SR.Activator of:
connexin 33.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Dihydroergocristine mesylate, 200 mg | sc-201117 | 200 mg | $58.00 | |||
Dihydroergocristine mesylate, 1 g | sc-201117A | 1 g | $255.00 |